However, early clinical trials with these biologics in patients with asthma were for the most par disappointing even though they were highly effective in animal models of asthma. It is becoming apparent that significant clinical effects with anti-cytokine-based biologic therapies are more likely in ...
Besides antibodies, other receptor blockers, such as recombinant IL-4 mutein that interferes with IL4Rα binding (Pitrakinra), was also tested in phase II clinical trials conducted on atopic asthmatics.16 Interestingly, when administered by inhalation, this mutein produced a significantly higher ...
INTRODUCTION Adoptive immunotherapy with donor conventional T cells (Tcons) and CD4+CD25+FOXP3+regulatory T cells (Tregs) is used to enhance immune reconstitution in clinical trials of haploidentical transplantation. Donor Tregs are infu... A Mancusi,S Bonato,RD Sordo,... - 《Blood》 被引量:...
Recombinant IL-21 exhibits a short half-life of 0.2 h in mice17 and 2 h in humans18, which has limited its therapeutic efficacy in clinical trials19. On the other hand, the use of viral vectors is associated with the risk of insertional mutagenesis and the development of anti-...
which has limited its therapeutic efficacy in clinical trials19. On the other hand, the use of viral vectors is associated with the risk of insertional mutagenesis and the development of anti-vector immunity, preventing their repeated administration. Moreover, the use of IL-21 as a monotherapy ...
A promising alternative would be the newly developed IL-4 receptor alpha antibody dupilumab which has been investigated in several clinical trials during the last years.Tsianakas, A.Luger, T. A.Expert opinion on biological therapyA. Tsianakas and T. A. Luger, "The anti-IL-4 receptor alpha ...
(ICIs) in immunocompetent preclinical models of renal cell carcinoma (RCC), with the goal of establishing the basis for testing these combinations in early phase clinical trials.Methods We engrafted tumors subcutaneously using two different syngeneic, immunocompetent murine RCC models: Renca and RAG....