Neutralizing monoclonal antibody against human IL-33 Anti-hIL-33-IgG (clone 19G8) is a monoclonal antibody (mAb) specific for human interleukin 33 (hIL-33). It is produced in hybridomas and purified by affinity chromatography. This antibody has been selected for its ability to efficiently neu...
human anti-il-33 neutralizing monoclonal antibody having an antagonistic effect on IL-33, especially the amino acid sequence of the framework region is an amino acid sequence of the germline or its combined amino acid sequence It is intended to provide a fragment of the body or its antibody. ...
Generation of tozorakimab, a potent, high‑affinity IL‑33 neutralizing antibody. The affinity of the lead mAb (33v20064) for IL-33red was at least 100,000-fold lower than the affinity of sST2 (< 90 fM) for IL-33red. Therefore, comprehensive affinity maturation was undertaken ...
Human anti-IL-33 neutralizing monoclonal antibody 专利名称：Human anti-IL-33 neutralizing monoclonal antibody 发明人：藤野 泰寛,吉川 勉,越智 宏 申请号：JP2017114387 申请日：20170609 公开号：JP6548696B2 公开日：20190724 专利内容由知识产权出版社提供 摘要：An object of the present invention is to ...
In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 ...
An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a ...
PROBLEM TO BE SOLVED: To provide a human anti-IL-33 neutralizing monoclonal antibody and an antibody competing with the antibody, as well as a cytokine expression inhibitor and a pharmaceutical composition for treatment, prevention, or alleviation of IL-33 related disease, which comprises those ...
human anti-il-33 neutralizing monoclonal antibody having an antagonistic effect on IL-33, especially the amino acid sequence of the framework region is an amino acid sequence of the germline or its combined amino acid sequence It is intended to provide a fragment of the body or its antibody. ...
An isolated human anti-IL-33 neutralizing monoclonal antibody or fragment thereof, wherein the antibody having an antagonistic action on IL-33, in particular the amino acid sequence of the framework region is the amino acid sequence of the germline amino acid sequence or a combination thereof To...
PROBLEM TO BE SOLVED: To provide an isolated human anti-IL-33 neutralizing monoclonal antibody or an antibody thereof having an antagonistic effect on IL-33, particularly in which the amino acid sequence of the framework region is an amino acid sequence of a germ line or a combination thereof...