merck millipore,默克密理博,ABS159,Anti-HPK1 Antibody 重要规格表 品种反应性主要应用宿主格式抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABS159 描述 Anti-HPK1 Antibody Alternate Names MEKKK 1 Mitogen-activated protein kinase kinase kinase kinase 1 Hematopoietic progenitor kinase MA...
产品编号:AHP1087查看说明书 产品名称:GOAT ANTI HUMAN HPK1 (N-TERMINAL) .0订购此产品 供应商:Serotec 规格:0.1 mg 目录价:￥:4681.13 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: 保存条件: 说明书地址:点击查看详细 打印此页关闭此页
HPK1 (Hematopoietic Progenitor Kinase 1) is a negative intracellular immune checkpoint that interferes with the priming and activation of T cells. In recent years, several HPK1 inhibitors have been discovered as novel immune-oncology drugs with promising potential to improve anti-tumor immune responses...
Enhanced anti-tumor efficacy in these models was achieved by combining HPK1 inhibitors with immune check-point blockers (ICBs) like anti-PD-1, anti-PD-L1or anti-CTLA4 antibodies3,4. HPK1 inhibition is a target for immuno-oncology treatment in cancers responsive or non-responsive to current ...
The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. Leuk Res 2012; 36: 884-888.Chen‑Deutsch X, Kutner A, Harrison JS and Studzinski GP: The pan‑caspase inhibitor Q‑VD‑OPh has ...
Syngeneic tumor models were used to assess anti-tumor activity of selected compounds as a monotherapy or combination therapy.Results: CRD1601 is a potent HPK1 inhibitor with a single digit nanomolar IC50 value in enzymatic assay and potent cellular activity in the SLP76 assay. A single dose of ...
Abstract 3967: ISM9182A, a novel HPK1 inhibitor, exhibits immune modulatory activity and robust monotherapy anti-tumor effects in preclinical studies doi:10.1158/1538-7445.AM2024-3967The hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a member of the Ste20 serine/threonine kinase super ...