It has been demonstrated that Chikusetsusaponin IVa (CsIVa) possesses abundant biological activities. Herein, using LPS to establish acute inflammation model of mouse liver and cell line inflammation model, we investigated whether miR-155/GSK-3β regulat
Activated microglial cells play an important role in immune and inflammatory responses in CNS and play a role in neurodegenerative diseases. We examined the effects of lipoic acid (LA) on inflammatory responses of BV-2 microglial cells activated by lipopolysaccharide (LPS), and explored the underlyin...
Currently, non- steroidal anti-inflammatory drugs are commonly used to treat these diseases in the clinic; for example, aspirin and ibuprofen are used to treat pain and fever caused by inflammation [Lewis et al., 1983]. Celecoxib, which has less bioavailability, is mainly used to treat ...
A potent Nrf-2 activator sulforaphane (SF), which is currently under clinical trials for cancer therapy, was employed to elucidate the role of Keap1/Nrf-2/ARE signalling pathway in T-cell responses. SF suppressed mitogen induced T-cell and B-cell proliferation. It also inhibited mitogen induce...
2.2. Elraglusib Enhances Tumor Cell Pyroptosis in a Co-Culture of Colorectal Cancer Cells and Immune Cells To determine if pyroptosis-mediated immune cell activity played a role in the co-culture results, we examined higher-power co-culture images for evidence of pyroptosis. Indeed, we observed...
[14]. Additionally, PLE0 plays a role in regulating epithelial–mesenchymal transition (EMT) by suppressing the expression of type II transforming growth factor beta receptor (TβRII) and the phosphorylation of TβRI in A549 lung cancer cells [15]. Additionally, a polysaccharide fraction (PLE-...