ARX788 is a next generation, site-specific anti-HER2 ADC that utilizes a unique non-natural amino acid enabled conjugation technology and a non-cleavable Amberstatin (AS269) drug-linker to generate a homogeneous ADC with a drug-to-antibody ratio of 1.9. ARX788 exhibits high serum stability ...
Each scFv consists of a VL domain of 107 amino acids, a peptide linker of 8 amino acids (GGGSGGGG), and a VH domain of 112 amino acids. The two scFvs associate asymmetrically to form a stable diabody (scFv dimer) with a molecular mass of 55 kDa. T84.66 diabody retains the high ...