A gene encoding a CAR containing: a single-chain antibody that contains specific heavy-chain CDR1 to CDR3 and specific light-chain CDR1 to CDR3, as defined in claim 1, and specifically binds to a human-derived GPC3 polypeptide; a transmembrane region fused to a carboxyl terminus of the ...
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174P Improved tumour penetration and efficacy of anti-GPC3 CAR-T cells in hepatocellular carcinoma via locoregional delivery doi:10.1016/j.annonc.2024.10.198Annals of OncologyP. WangB. Feng
1. AbelZeta Pharma Announces Agreement withAstraZenecato Co-Develop a novel Glypican 3 (GPC3) Armored CAR-T Therapy inChina.December 2023.https://www.abelzeta.com/abelzeta-pharma-announces-agreement-with-astrazeneca-to-co-develop-a-novel-glypican-3-gpc3-armored-car-t-therapy-in...
a CAR including said anti-GPC3 single-chain antibody; an immunocompetent cell expressing said CAR; an anti-GPC3 antibody gene or CAR gene; a vector including said anti-GPC3 antibody gene or CAR gene; a host cell into which said vector has been introduced; a method for specifically detecting...
A CAR containing a single-chain antibody against GPC3 and an anti-GPC3 single-chain antibody capable of recognizing an epitope different from existing antibodies (eg, GC33, GC199) and capable of specifically binding to GPC3 located on the cell membrane. , Providing immunocompetent cells expressing...
a CAR including said anti-GPC3 single-chain antibody; an immunocompetent cell expressing said CAR; an anti-GPC3 antibody gene or CAR gene; a vector including said anti-GPC3 antibody gene or CAR gene; a host cell into which said vector has been introduced; a method for specifically detecting...
Conclusions CRISPR-edited anti-GPC3 CAR-T cell therapies are a promising potential option for the treatment of HCC. We have shown that our allogeneic anti-GPC3 CAR-T cells have significant activity both in vitro and in vivo against HCC-derived cell lines, and this activity is further improved...
an immunocompetent cell expressing the CAR; a gene of the anti-GPC3 antibody or a gene of the CAR; a vector comprising the anti-GPC3 antibody gene or the CAR gene; a host cell in which the vector has been introduced; a method for specifically detecting GPC3; and a kit for specifically...
an immunocompetent cell expressing the CAR; a gene of the anti-GPC3 antibody or a gene of the CAR; a vector comprising the anti-GPC3 antibody gene or the CAR gene; a host cell in which the vector has been introduced; a method for specifically detecting GPC3; and a kit for specifically...