We identified anti-GM-CSF autoantibodies as the cause of disseminated nocardiosis in a previously healthy and apparently immunocompetent adult. This case emphasizes the importance of including ACA in the differential diagnosis of PID, especially in previously healthy adults. Importantly, anti-GM-CSF ...
their manuscript Sakagami et al. also report the coincidental finding that anti-CD20 mediated B cell depletion is strongly enhanced and B cell reconstitution is strongly suppressed in the presence of such anti-GM-CSF autoantibodies. There is currently no mechanistic theory however, that could explain...
Cryptococcosis is a potentially life-threatening fungal disease caused by encapsulated yeasts of the genusCryptococcus, mostlyC. neoformansorC. gattii.Cryptococcal meningitis is the most frequent clinical manifestation in humans. Neutralizing autoantibodies (auto-Abs) against granulocyte鈥搈acrophage colony-...
We performed Anti-GM-CSF autoantibody ELISA assays in the patient's sera and all of three serum samples revealed a high titer of anti-GM-CSF autoantibodies. The patients were treated with amphotericin B deoxycholate with or without flucytosine for induction antifungal therapy, followed by ...
This effect was limited to their IgG fraction. Anti-GM-CSF autoantibodies are associated with some cases of cryptococcal meningitis in otherwise immunocompetent patients. These cases need not have associated PAP.EBSCO_AspJournal of Immunology
TRA-8 treatment depleted these cells and resulted in a significant reduction of autoantibodies and inflammation. In human RA synovial cells, the expression of IRF5 and DR5 was negatively correlated with PTPN6. TRA-8, but not TRAIL, suppressed RA inflammatory MØ and Th17 cells in the low ...
Anti-GM-CSF Autoantibodies and Cryptococcus neoformans var. grubii CNS VasculitisAnti-GM-CSF autoantibodiesCryptococcusmeningitisvasculitisstrokeJournal of Clinical Immunology -doi:10.1007/s10875-020-00796-5Segolene PerrineauRomain GueryDelphine Monnier