在成人ECMO中,出凝血紊乱事件发生率也较高,达到33%。当前临床上常用的监测工具包括:ACT,APTT,anti-Factor Xa,TEG和ROTEM等。 ACT: ACT延长除了肝素外,血液稀释、血小板数量减少和功能障碍、低体温、低纤维蛋白原血症、凝血因子缺乏等...
Walid SalibaOrna NitzanWasseem RockGilat RonLuci ZalmanLee GoldsteinIdit LaviMazen EliasSpringer-VerlagAnnals of HematologySaliba W, Nitzan O, Rock W, et al. Non-therapeutic anti-FXa levels are common among medical ward patients treated with enoxaparin. Ann Hematol. 2011;90:1345-1351....
Relationship between measured anti-FXa and the concentration of low molecular weight heparin (LMWH).doi:10.1371/journal.pone.0116835.g003O. ThomasEmanuel LybeckK. StrandbergN. TynngrdU. SchttPLOS ONE
One of the limitations is the large sample dilution in the assay setup, which causes dissociation of the inhibitor from the AnXa-inhibitor complex (due to the reversible binding equilibrium of the AnXa-inhibitor), resulting in an erroneous elevation of the anti-FXa activity following AnXa ...
Antiprothrombin antibodies induce platelet activation: a possible explanation for anti‐FXa therapy failure in patients with antiphospholipid syndrome? 来自 科研支点 喜欢 0 阅读量: 28 摘要: Background Arterial and venous thrombosis are both common in antiphospholipid syndrome (APS). Recent studies have ...
794: Placental findings following adjusting enoxaparin dosage according to anti-FXa levels in thrombophilic women. a randomized controlled trialAs the obesity pandemic continues in the United States, obesity in pregnancy has become an area of interest. Many studies focus on women with body mass index...
Reversibility of the anti-FXa activity of idrabiotaparinux (biotynilated idraparinux) by intravenous avidin infusion. J Thromb Haemost 2010; 8: 722-9.Paty I, Trellu M, Destors JM, et al. Reversibility of the anti- FXa activity of idrabiotaparinux (biotinylated idraparinux) by ...
Hemostatic efficacy and reversal of anti-FXa activity with andexanet were assessed in patients from the ANNEXA-4 study (Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXa Inhibitors) with intracranial hemorrhage (ICrH).Demchuk, Andrew M.Yue, PatrickZotova, ElenaNakamya, ...
Fluorogenic anti-FXa assays have the potential to offer greater benefits over chromogenic assays in terms of greater specificity, sensitivity and they are not so influenced by sample opacity or turbidity. Commercial plasmas were spiked with pharmacologically relevant concentrations (0–1 U/ml) of UFH...
binds to fixed in the presence of fixed and zymogen of factor ix (fixz), and antibodies that specifically bind to factor x zymogen (fxz), wherein the anti-fxz antibody or an antigen-binding portion thereof preferentially binds to fxz in the presence of fxz and activated factor x (fxa)....