The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. 来自 国家科技图书文献中心 喜欢 0 阅读量: 44 作者:C Li,S Piran,P Chen,S Lang,A Zarpellon,JW Jin,G Zhu,A Reheman,dWDE Van,EK ...
Efficacious therapies which decrease systemic levels of pathogenic antibodies include treatment with IVIG therapeutic plasmapheres... L. Ling,S Roy,T Daly,... - 《Blood》 被引量: 0发表: 2015年 M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety across the Full Range of ...
No serious infections were seen.\nBaseline disease characteristics suggested a difficult to treat population, with a median of 5.8 years ITP duration, 4 prior ITP therapies and approx. 30% of pts having previously received thrombopoetin receptor agonists (Table 2). More pts receiving a single (...
Harbour BioMed (“HBM”, HKEX: 02142) today announced last patient dosing in a phase 1b/2a study of its anti-FcRn antibody, batoclimab (HBM9161), for the treatment of acute neuromyelitis optica spectrum disorder (NMOSD). This clinical study aims to assess the safety, tolerability, pharmacod...
Controlled T-cell redirection is a potential lethal weapon against cancer but comes with the cost of non-specific overstimulation of the immune system observed with bispecific T-cell engager therapies3,4,8. Circumvention by removal or silencing of the Fc fragment are the standard strategies employed...