AB0433 Tnf-inhibitors and anti-b- cell treatment in patients with rheumatoid arthritis. real-world data from the russian north-western biological treatment cohortdoi:10.1136/ANNRHEUMDIS-2018-EULAR.6211E. VasilenkoR.R. SamigullinaV.I. Mazurov...
In Escherichia coli, programmed cell death is mediated through ``addiction modules'' consisting of two genes; the product of one gene is long-lived and toxic, whereas the product of the other is short-lived and antagonizes the toxic effect. Here we show that the product of λ rexB, one ...
Importantly, a F(ab') 2 fragment of Anti-B1 Antibody induced apoptosis, while the Fab fragment did not, indicating that the Fc region was not required and dimerization of CD20 may be sufficient for induction of apoptosis. In contrast, rituximab, which binds to an overlapping epitope on CD20...
In addition to the regulatory effect on T cells, carp Il10 stimulates proliferation, differentiation, and Ab secretion by IgM+ B cells. Overall, carp Il10 shares several prototypical activities with mammalian IL-10, including downregulation of the inflammatory response of phagocytes, stimulation of...
In addition, the combination of CTLA4 blockade and Ab targeting of tumor to DCs is an effective method for the cross-presentation of tumor cell antigens. 展开 关键词: Anti-CD20 Cross-presentation Dendritic cell Idiotype Vaccine.DOI: 10.1097/00002371-200211000-00002 ...
Human NK cells lyse Ab-coated target cells through the process of Ab-dependent cellular cytotoxicity (ADCC). Improving ADCC responses is desirable because it is thought to be an important antitumor mechanism for some Abs. NK cell inhibitory receptors, such as killer cell Ig-like receptors, engage...
2.可逆性:抗原与抗体结合形成抗原抗体复合物的过程是一种动态平衡,其反应式为:Ag+AbAg·Ab; 3.适当浓度和比例; 4.敏感性:在测定血清中某一物质的含量时,化学比色法的敏感度为mg/ml水平,酶反应测定法 5.酸碱度:合适的pH为6-8。 6.温度:37℃通常是抗原体反应最适温度。
The anti-PD-L1 mAb avelumab is unique among checkpoint inhibitors in that it is a fully human IgG1 capable of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) of PD-L1-expressing tumor cells. Here, we investigated avelumab as a potential therapy for chordoma. We examined 4 ...
In this study, the tumor sections were stained with phospho-ATM (Ser 1981, 1:100) (Abcam, #ab81292, Cambridge, UK), phospho-ATR (Ser 428, 1:100) (Abcam, #ab178407), P53 (1:100) (Abcam #ab1101), phospho-P53 (Ser 15, 1:100) (Cell signaling technology, #9284S, MS, USA), ...
In this paper the chaotic control problem of nerve cell network of two neurons with delays and the chaotic anti-control problem of complex network are studied.By using Open Plus Nonlinear Closed Loop(OPNCL) method,a kind of controller of the chaotic neural network is designed.The theoretical an...