Ivonescimab+AK117 近日,康方生物(9926.HK)宣布其自主研发的全球首创的PD-1/VEGF双特异性抗体依沃西联合新一代D47单抗莱法利(AK117)对比帕博利珠单抗一线治疗PD-L1阳性(CPS≥1)复发转移性头颈部鳞癌(R/M HNSCC)随机、对照、多中心、III期临床研究(AK117-302)完成首例患者入组。华中科技大学同济医学院附属协和医院...
Way to achieve the processing on the effective amount of an anti-CD47 drugMethod applies treatment effective dose anti-CD47 before being used to treat the anti-CD47 agent for having therapeutic dose application priming paint agent is acted on behalf of to object. Turnover cell starts the ...
2015, Nature Reviews Drug Discovery The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors 2012, Proceedings of the National Academy of Sciences of the United States of America Cancer immunotherapy via dendritic cells 2012, Nature Reviews Cancer Vie...
Beyond their role as drug carriers and their injectability, the most significant advantage of TSI gels is their ability to solidify in situ at body temperature, which helps to preserve the drug during intratumoral injection and improves treatment outcomes [11]. The later therapeutic strategy ...
Our group has summarized the crucial impacts of tissue macrophages on drug responses in various types of human diseases [7]. However, whether macrophages are involved in regulating the therapeutic effectiveness of HDACi in cancer remains unknown by far. In the present study, we for the first ...
The specific targeting, drug delivery, and anti-tumor efficacy of the anti-CD47 ADC were investigated in vitro and in vivo. Furthermore, immune response analysis detected an increase of immune cells in lymph nodes and infiltration of macrophage in tumor but no general immune toxicity in the ...
Anti-drug'是国际上通用的禁毒相关术语,主要用于描述反对毒品滥用或推广禁毒措施的行动。其核心在于通过教育、法律、社会宣传等手段预
Adv Drug Deliv Rev. https://doi.org/10.1016/j.addr.2019.12.001 Article PubMed Google Scholar Zhang M, Hutter G, Kahn SA, Azad TD, Gholamin S, Xu CY et al (2016) Anti-CD47 treatment stimulates phagocytosis of glioblastoma by M1 and M2 polarized macrophages and promotes M1 polarized ...
'Anti-doping screening'强调筛查功能 'Drug testing in sports'为通俗化表达 该检测体系通过技术手段(如质谱分析)与法律框架(如《反兴奋剂管理办法》)的双重保障,已成为现代体育不可或缺的组成部分。随着基因编辑等新技术发展,检测范围已从传统药物扩展至基因兴奋剂等新型违规手段。
Antibody-drug conjugates (ADC) have been shown to enable HSCT within and across immunological barriers in preclinical models with fewer adverse effects (Persaud et al (2021); J Clin Invest), but even ADCs have toxicity risks caused by systemic exposure to the highly potent compounds used as ...