An alternative hypothesis, therefore, is that increased toxicity in the CC genotype would offset the drugs’ benefit; however, neither our study nor the other adult study showed any difference in response rates between genotypes. This lack of any benefit for the CC genotype in adult AML suggests...
An alternative hypothesis, therefore, is that increased toxicity in the CC genotype would offset the drugs' benefit; however, neither our study nor the other adult study showed any difference in response rates between genotypes. This lack of any benefit for the CC genotype in adult AML suggests...
Investigational New DrugsPhase I studies of AVE9633,an anti-CD33antibody-maytansinoid conjugate,in adult patients with relapsed/refractory acute myeloid leukemia. Lapusan S,Vidriales MB,Thomas X,et al. Investigational New Drugs . 2012Lapusan, S., Vidriales, M.B., Thomas, X., de Botton, S.,...
- 《Investigational New Drugs》 被引量: 68发表: 2012年 Treatment of patients with relapsed or refractory acute myelold leukemia (AML) with recombinant engineered human anti-CD33 antibody-calicheamicin drug conj... Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and...
Introduction Despite the approval of several new drugs, deaths from acute myeloid leukemia (AML) remain common. Because of well-defined cell surface antige... RB Walter - 《Expert Opinion on Biological Therapy》 被引量: 0发表: 2022年 A Phase I Study of Lintuzumab Ac225 in Combination with...
An alternative hypothesis, therefore, is that increased toxicity in the CC genotype would offset the drugs' benefit; however, neither our study nor the other adult study showed any difference in response rates between genotypes. This lack of any benefit for the CC genotype in adult AML suggests...
- 《Investigational New Drugs》 被引量: 68发表: 2012年 In vitro experimental 211At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO...
Methods and Results - Drugs were administered via the brachial artery in healthy male volunteers and forearm blood flow was measured by venous occlusion plethysmography. Inhibition of K-IR by barium chloride (4 mumol min(-1)) alone or with additional inhibition of Na+/ K+ ATPase (ouabain 2.7...
Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapy Mol Cancer Ther, 11 (4) (2012), pp. 1017-1025 Google Scholar 30 E Pardon, T Laeremans, S Triest, et al. A general protocol for the generation of nanobodies for structural biology Nat Protoc...