Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). Product Details ...
Levels of circulating CD14(high)CD16(+) monocytes increase in atherosclerotic patients and are predictive of future cardiovascular events. Platelet activation has been identified as a crucial determinant in the acquisition of a CD16(+) phenotype by classical CD14(high)CD16(-) cells. We tested ...
Exercise training-induced lowering of inflammatory ( CD14+ CD16+) monocytes: a role in the anti-inflammatory influ- ence of exercise[J]. J Leukoc Biol, 2008,84(30): 1271- 1278.Timmerman, K. L., Flynn, M. G., Coen, P. M., Markofski, M. M., and Pence, B. D. (2008). ...
Background Anti-PD-1 and anti-CTLA-4 immunotherapies have become the standard of care for metastatic melanoma. However, the majority of patients develop resistance to therapy. Macrophages are abundant cells in tumours, but their role in immunotherapy response and resistance is largely unknown. This...