CBASS and Pycsar are anti-phage defense systems in diverse bacteria that use cyclic nucleotide signals to induce cell death and prevent viral propagation. Phages use multiple strategies to defeat host CRISPR and restriction-modification systems, but no mechanisms are known to evade CBASS and Pyc...
CBASS anti-phage nucleotide second messenger Introduction cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are signaling proteins in bacteria and animals, which sense viral infection and synthesize nucleotide second messengers to initiate antiviral defense (Kranzusch, 2019; Whiteley et al., 20...
PROTEINS THAT INHIBIT CYCLIC-OLIGONUCLEOTIDE-BASED ANTI-PHAGE SIGNALING SYSTEM (CBASS)Anti-CBASS proteins and methods of their use are provided.
We show that a locus containing two CBASS and one type III-B CRISPR-Cas system, regulated by the transmembrane anti-σ DdvA and its cognate extracytoplasmic function (ECF) σ DdvS, can defend Myxococcus xanthus against a phage. Cryo–electron microscopy reveals DdvA-DdvS pairs assemble as ...
Using a screen of 975 type I CBASS operon-phage challenges, we show that operons with distinct cGAS/ DncV-like nucleotidyltransferases (CD-NTases) and CD-NTase-associated protein (Cap) effectors exhibit marked patterns of phage restriction. We find that some type I CD-NTase enzymes ...
抗癌药物新剂型学术论文集=A COLLECTION OF ACADEMIC TREATISE ON NEW DOSAGE FORMS For anti-tumor agents沈阳药学院顾学裘