Bai et al. recently leveraged six-membered lactam glutamine mimic as a structural motif for the design of α-acyloxymethylketone warhead peptidomimetic scaffolds. Pleasingly, the compounds23–25were pinpointed to be potent inhibitors of SARS-CoV-2 3CLpro. Specifically, the compound23–25inhibited ...
Because of the anti-inflammatory role of IL-1RA, we focused on binding of transcription factors to the IL-1RA promoter. An inhibitory element and three positive-acting LPS-response elements (LRE-1, LRE-2 and LRE-3) in the IL-1RA promoter, including NFκB, PU.1 and NFIL-6 sites, ...
Further examination of the C-terminal tail sequences suggested that the motif (KTAKP) might be a putative PKC-a/b target site (Supplementary Figure 3A). We first tested the outcome of modifying PKC activity (on H1.1 and H1.3 in apoptosis assays), using pharmacological approaches. In the ...
Because of the anti-inflammatory role of IL-1RA, we focused on binding of transcription factors to the IL-1RA promoter. An inhibitory element and three positive-acting LPS-response elements (LRE-1, LRE-2 and LRE-3) in the IL-1RA promoter, including NFκB, PU.1 and NFIL-6 sites, ...