这些结果将嗜碱性粒细胞定义为以前未被认识到的抗ASGM1介导细胞消耗的靶标,并引起人们对嗜碱性粒细胞的关注,而不是NK细胞或除了NK细胞外对抗ASGM1处理的小鼠中观察到的某些表型。 参考文献:Nishikado H, Mukai K, Kawano Y, et al. NK cell-depletinganti-asialo GM1 antibody exhibits a lethal off-targeteff...
欲了解详情请点击 [1]Nishikado H, Mukai K, Kawano Y, et al. NK cell-depletinganti-asialo GM1 antibody exhibits a lethal [3]off-target effect on basophils invivo[J]. The Journal of Immunology, 2011, 186(10): 5766-5771. [2] Kasai, M., Iwamori, M., Nagai, Y., Okumura, K. a...
ASGM 1 expression on these CTL, as determined by sensitivity to antibody plus complement (C), appeared to be highly variable and dependent on two factors鈥攖he nature of the antigenic stimulus (viral vs. alloantigen), and the mouse strain from which the CTL originated. Thus, ASGM 1 antigen...
BMS-986012 is a nonfucosylated, first-in-class, fully human immunoglobulin G1 monoclonal antibody that binds to fucosyl-GM1. Methods CA001-030 is a phase 1/2, first-in-human study of BMS-986012 as monotherapy or in combination with nivolumab for adults with relapsed or refractory SCLC. ...
(2019). Targeted delivery of TNF potentiates the antibody-dependent cell-mediated cytotoxicity of an anti-melanoma immunoglobulin. Journal of Investigative Dermatology, 139(6), 1339-1348. [15] Turaj, A. H., Dahal, L. N., Beers, S. A., Cragg, M. S., & Lim, S. H. (2017). TLR...
参考文献:Nishikado H,Mukai K,Kawano Y,et al.NK cell-depletinganti-asialo GM1 antibody exhibits a lethal of-target efect on basophils invivo[J].The Journal of lmmunology, 2011,186(10):5766-5771 ·研究肿瘤的免疫治疗 肿瘤的发展过程包括血管新生,肿瘤尺寸增大和肿瘤转移。使用CXCL14/BRAK(CXCL1...
Systemic lupus erythematosus demonstrating serum anti-GMI antibody with sudden onset of foot drop as the initial presentation. Intern Med 1999; 38: 729- 732.Matsuki Y, Hidaka T, Matsumoto M, Fukushima K, Suzuki K. Systemic Lupus erythematosus demonstrating serum anti-GM1 antibody, with sudden ...
Various antibody parameters remained fairly constant for 1 year, in additional serum samples taken at 4-month intervals. Such anti-GM1 IgG1-antibodies were not detected in > 100 other normal serum samples tested, indicating a very low frequency in the general population. The low affinity of ...