Accelerated atherosclerosis often occurs in patients with antiphospholipid syndrome (APS), and autoantibodies to beta(2) glycoprotein I (anti-beta(2)GPI) are confirmed as pathogenic antibodies to APS. Our previous studies have demonstrated that the conversion of mouse peritoneal macrophages into foam ...
The invention relates to an anti-beta 2GPI gene engineering antibody disclosed by ZhangXiuRu, wherein the characters of the antibody comprise 1, the antibody only has univalence, 2, the antibody has no Fc segment and can not activate complement, therefore, the self epitope can be sealed and...
We found that anti-beta(2)GPI/beta(2)GPI immune complex induced NETs formation in a time- and concentration-dependent manner. This effect was mediated by its interaction with TLR4 and the production of ROS. We demonstrated that MyD88-IRAKs-MAPKs, an intracellular signaling pathway, was ...
Anti-beta2-glycoprotein I (GPI) autoantibodies, annexin V binding and the anti-phospholipid syndrome. Clin Exp Immunol 2000;120:537-43.Anti‐β2‐glycoprotein I (GPI) autoantibodies, annexin V binding and the anti‐phospholipid syndrome[J] . J. G.Hanly,S. A.Smith.Clinical & Experimental ...
Anti-beta2-glycoprotein I (GPI) autoantibodies, annexin V binding and the anti-phospholipid syndrome. Clin Exp Immunol 2000;120:537-43.Hanly JG, Smith SA. Anti-beta2-glycoprotein I (GPI) autoanti- bodies, annexin V binding and the anti-phospholipid syndrome. Clin Exp Immunol 2000;120:537-...
anti-β2-GPI antibody" is preferably used in the method of the present invention, which preferably comprises at least a step for forming a sandwich complex represented by "the anti-apoB antibody and/or anti-β2-GPI antibody"-"the complex of oxidized LDL and CRP"-"the anti-CRP antibody"...
HLA-DPB1 alleles association of anticardiolipin and anti-2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Lupus 2003;12:560-3.Sebastiani GD,Galeazzi M,Tincani A. HLA-DPB1 alleles association of anticardiolipin and anti-beta2GP1 antibodies in a large...
Conclusions These results suggest that some anti-DNA antibodies show dual reactivity with CL-beta2-GPI via DNA, and this may contribute to the high percentage of association with SLE in APS. Such an antibody can enter live cells with DNA, and activate intracellular DNA sensors to induce tissue...
Introduction: Anti-beta 2GPI-Domain 1 (beta 2GPI-D1) antibodies are considered to be a pathogenic subset of anti-beta 2GPI antibodies and have been strongly associated with thrombosis and pregnancy morbidity in patients with antiphospholipid syndrome (APS). We evaluated the clinical utility of ...
Additionally, the promotion effect of the oxLDL/beta(2)GPI/anti-beta(2)GPI complex on both proliferation and apoptosis, as well as signaling pathway activation, was stronger than that of the other control groups. The use of selective blockers showed that TLR4/NF-kappa B and ERK1/2 partly...