We found that anti-beta(2)GPI/beta(2)GPI immune complex induced NETs formation in a time- and concentration-dependent manner. This effect was mediated by its interaction with TLR4 and the production of ROS. We demonstrated that MyD88-IRAKs-MAPKs, an intracellular signaling pathway, was ...
Involvement of annexin A2 in anti-132GPI/132GPI-induced tissue factor expression on monocytes [ J ]. Cell Research, 2007,17 (8) : 737 - 739.Zhou H, Ling S, Yu Y, et al. Involvement of annexin A2 in anti-beta2GPI/beta2GPI- induced tissue factor expression on monocytes. Cell Res ...
Accelerated atherosclerosis often occurs in patients with antiphospholipid syndrome (APS), and autoantibodies to beta(2) glycoprotein I (anti-beta(2)GPI) are confirmed as pathogenic antibodies to APS. Our previous studies have demonstrated that the conversion of mouse peritoneal macrophages into foam ...
The invention relates to an anti-beta 2GPI gene engineering antibody disclosed by ZhangXiuRu, wherein the characters of the antibody comprise 1, the antibody only has univalence, 2, the antibody has no Fc segment and can not activate complement, therefore, the self epitope can be sealed and...
Anti-beta2-glycoprotein I (GPI) autoantibodies, annexin V binding and the anti-phospholipid syndrome. Clin Exp Immunol. 2000; 120:537-43. [PubMed: 10844535]Hanly JG, Smith SA. Anti-beta2-glycoprotein I (GPI) autoantibodies, annexin V binding and the anti-phospholipid syndrome. Clin Exp ...
Anti-beta 2GPI Antibodies Induce Oxidative and Nitrative Stress in Endothelial Cells through Activation of Discrete Nox Isoforms and eNOS UncouplingKunduSumanAlluriRaviKumarMeifangMcCraeKeithR.Blood: The Journal of the American Society of Hematology...
Anti-beta2-glycoprotein I (GPI) autoantibo- dies, annexin V binding and the anti-phospholipid syndrome. Clin Exp Immunol 2000; 120: 537-543.Hanly JG, Smith SA. Anti-beta2-glycoprotein I (GPI) autoantibodies, annexin V binding and the anti-phospholipid syndrome. Clin Exp Immunol 2000;120:...
Antibodies to anionic phospholipids and anti-2- GPI: association with thrombosis and thrombocytopenia in systemic lupus erythematosus. Human Immunol 2003;64:265-273.Amoroso A, Mitterhofer AP, Del Porto F, et al. : Antibodies to anionic phospholipids and anti-beta2-GPI: association with ...
Sebastiani GD, Galeazzi M, Tincani A, Scorza R, Mathieu A, Passiu G, et al. HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Lupus 2003;12(7):560-3....
Introduction: Anti-beta 2GPI-Domain 1 (beta 2GPI-D1) antibodies are considered to be a pathogenic subset of anti-beta 2GPI antibodies and have been strongly associated with thrombosis and pregnancy morbidity in patients with antiphospholipid syndrome (APS). We evaluated the clinical utility of ...