Joachim Müller, Andrew Hemphill, in International Review of Cell and Molecular Biology, 2013 3 Kinds of Drug Targets 3.1 Drug Targets in the Gene-Expression Machinery 3.1.1 DNA Intercalating Agents Among the first antiparasitic drugs are compounds that directly intercalate into DNA. The acridin...
Microbial skin infections, antibiotic resistance, and poor wound healing are major problems, and new treatments are needed. Our study targeted solving this problem with Nigella sativa (NS) oil and photodynamic therapy based on methylene blue (MB-PDT). An
TNKS1BP1 Rabbit Polyclonal Antibody (CAB20388) €139 - €419 Choose Options Antibody Size: Required 20uL 100uL Current Stock: Quantity: Decrease Quantity: Increase Quantity: PTPN12 Rabbit Polyclonal Antibody (CAB20569) €139 - €419 Choose Options Antibody Size: Required 20uL 100uL Current...
Fu et al. [20] confirmed in 2022 that icariin inhibits the growth of ovarian cancer tumors by targeting miR-1-3p/TNKS2/Wnt/β-catenin signaling. Beyond common flavonoids, there are many polyphenolic compounds with anti-tumor activity in Chinese herbal medicine. For example, tanshinone IIA, a...
Icariin attenuates the tumor growth by targeting miR-1-3p/TNKS2/Wnt/β-catenin signaling axis in ovarian cancer. Front. Oncol. 2022, 12, 940926. [CrossRef] 21. Liu, B.; Liu, L.; Zang, A.; Song, Z.; Yang, H.; Wang, Z.; Shang, Y.; Ma, T.; Zhang, Y. Tanshinone IIA ...
molecular biology in the 21st century still remains in finding the weak spot of HIV's infection. This is because the chemical binding mechanism of such fusion (producing a pore by which the virus discharged its capsid into cells' nucleus, so infecting it forever) has not been elucidated [1]...
It is anticipated that P9 could serve not only as a new chemical tool to interrogate SHP2 biology but also as a starting point for the development of novel therapeutics targeting SHP2. Keywords: protein tyrosine phosphatase; SHP2; target protein degradation; PROTAC; anti-cancer agent 1. ...
VAAHCFAASPYNNNNYNIDTTTRC 2 67.56 SSADVEVLCCDTNK 2 115.40 CLNTPLPLIYTTCPIGQDK 2 68.32 KCLNTPLPLIYTTCPIGQDK 2 47.13 YSVCCSTDK 2 62.70 YSVCCSTDKCNK 3 137.57 TTMFFPNHPVLLMGCTYNCPTER 2 58.44 SSADVVVVCCDTNKCNK 2 115.4 CLNTPLPLIYTTCPIGQDK 2 68.32 KCLNTPLPLIYTTCPIGQDK Toxins 2014, 6 ...
The Paradigm of DprE1 and MmpL3 Giulia Degiacomi 1,†, Juan Manuel Belardinelli 2,† , Maria Rosalia Pasca 1 , Edda De Rossi 1, Giovanna Riccardi 1,* and Laurent Roberto Chiarelli 1,* 1 Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia...