Objectives To evaluate the frequency of patient concerns about drug-related side effects among anti-TNF users and to delineate the factors predicting an increase in concerns aboutanti-TNF drugs. Methods Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)patients who...
Biologic therapy involving anti-tumor necrosis factor-α (anti-TNFα) agents has fundamentally changed the management of patients with immune-media
Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory ...
V. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81, 495–504 (1995). CAS PubMed Google Scholar Rothe, M. et al. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83, ...
Notably, NTG exerted a similar dose-dependent anti-inflammatory effect on cells activated with TNF-α (Fig. 1C). NTG Enhances Endothelial NO Production. The potent and hitherto-unknown anti-inflammatory effect of NTG expectedly resulted from an increase in endothelial NO production, as ...
Anti inflammatory agents like aspirin, celecoxib, and ketorolac are used in various cancer treatment and show anticancer effects (Thun et al., 2002; Wong, 2019). However, prolonged administration of these drugs is also associated with severe side effects (Rothwell et al., 2012, 2011; Wiart...
Side effects, mainly infections and allergic reactions, occur similar to those observed in RA treatment. Currently, there is no reason to combine TNF-alpha blockers with other disease-modifying anti-rheumatic drugs (DMARDs) for the treatment of AS and other SpA, as these DMARDs are not ...
Integrin-αvβ3 mediates FGF-2- and (tumor necrosis factor-α) TNF-α-induced angiogenesis, while integrin-αvβ5 mediates VEGF- and TGF-α-induced angiogenesis [74]. Amongst all integrins, αvβ3 is the most frequently targeted due to high potential as angiogenic factor [50]. MCAM (CD...
Plasma and CSF samples were diluted 2-fold for the V-plex Pro-inflammatory panel 1 (IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, and TNF-α), Cytokine Panel 1 (1L-1α IL-5, IL-7, IL-12/23p40, IL-15, IL-16, IL-17A, TNF-β, and VEGFA) and ...
Approximately 30% of IBD patients do not respond to anti-TNF therapy (primary non-responders), and nearly half of those who initially benefit from these drugs experience a loss of clin- ical benefits within the first year, necessitating dose esca- lation or treatment alteration, referred to as...