596. AAV Gene Delivery of the Anti-Tau Antibody PHF1 Reduces Brain Tau Pathology in P301L MiceAnti-tau immunotherapy has been proposed as a promising therapy for various tauopathies including Alzheimer's disease (AD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP). However...
We investigated the therapeutic efficacy of two different antibodies that specifically target acetylated lysine 174 on tau (ac-tauK174). We treated PS19 mice, which harbor the P301S tauopathy mutation that causes FTLD, with anti-ac-tauK174 and measured effects on tau pathology, neurodegeneration,...
In this study, we assessed the potential of four anti-tau sdAbs as gene therapy by expressing them transgenically in tauopathy flies. Furthermore, by taking advantage of the ease of genetic manipulation in the flies, we explored their efficacy not only in all neurons but also in different ...
作者: バダー,マルティン,ゲプフェルト,ウルリヒ 摘要: In this specification, a non-covalent complex between a haptenized antibody that specifically binds to human Tau (pS422) and an anti-blood brain barrier / hapten bispecific antibody is reported. 年份: 2015 收藏...
Other new technologies such as the brain shuttle modification or PEST fusion can enhance the penetration of antibody-based drugs into the central nervous system and improve clinical outcomes; additionally, antibodies recognizing Toll-like receptor 2 and tau oligomers are potential therapeutic tools [147...
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG+memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated VH5–51/VL4–1 antibodies. One of these, CBTAU...
Oligomeric forms of amyloid-β (Aβ) and tau are increasing being recognized as key toxins in the pathogenesis of Alzheimer’s disease (AD). We developed a novel monoclonal antibody (mAb), GW-23B7, that recognizes β-sheet secondary structure on patholog
Triple-transgenic mice, harbouring presenilin 1 (PSEN1; also known as PS1), amyloid-β precursor protein (APP) and microtubule-associated protein tau (MAPT) transgenes. They progressively develop amyloid-β deposition and neurofibrillary tangles as in Alzheimer disease. Neutropenia The presence of abn...
Recombinant adeno-associated virus (rAAV) was utilized to express these antibody fragments in homozygous JNPL3 P301L tau mice. Two iBs (CP13i, PHF1i) and one scFv (PHF1s) abrogated tau pathology and delayed time to severe hindlimb paralysis. In a second tauopathy model (rTg4510), CP13...
Anti-Aβ antibody binding was found to pro- mote the clustering of CD68-positive microglia around plaques. The treatment increased plaque compaction, reduced the formation of tau-positive dystrophic neur- ites, and led to an overall decrease in tau immunoreactiv- ity in the hippocampal formation...