Tear function and ocular surface were evaluated by Schirmer I test, tear break up time, and rose bengal staining. Dry eye symptom scores were recorded. Results: Increased levels of anti-Ro/SSA and anti-La/SSB antibodies were detected in sera of 57.1% and 50% of SS patients, respectively....
Clinical data primarily include clinical symptoms, the duration of NMOSD, Expanded Disability Status Scale (EDSS) at the moment of collecting the blood sample, relapse rate, serum AQP4-IgG. All data were compared between NMOSD patients who had anti-SSA/Ro antibody and those who did not. The ...
Anti-TNFalpha single-chain variable fragment (scFv) monoclonal antibody (mAb). c Intracameral (IC) injection. While half-life is the most common elimination parameter reported for ocular drugs, clearance is the fundamental PK parameter, defined as the proportionality constant relating concentra...
Antibody to ds-DNA are directed against the phosphate-deoxyribose backbone of the DNA molecule, and appear to be generated due to preferential activation of specific B cells and are not merely due to polyclonal B-cell hyperactivity prior to exacerbation of SLE. The common DNA idiotype (Id), ...
All blood tests were performed, as part of a research biomarker project, in a Good Clinical Practice accredited clinical laboratory (Unità Operativa Complessa Medicina di Laboratorio, Azienda Ospedaliera di Padova laboratory within Istituto Oncologico Veneto) according to automated or semi-automated ...
Methods: Convenient sampling was used to collect blood samples from 135 patients attending anti retroviral therapy from February to March 2015. Serum samples were tested for anti-Toxoplasma gondii(T. gondii) antibody by using latex agglutination test. Structured questionnaire was used to collect data ...
antibody, Anti-receptor antibody, Anti-reticulin antibody, Anti-ribosomal antibody, Anti-Ro/SSA antibody, Anti-single-stranded DNA antibody, Anti-striated muscle antibody, Anti-thyroglobulin antibody, Antithyroid antibody, Antithyroid peroxidase antibody, Anti-tumor necrosis factor- α monoclonal antibody,...
22 Together, these data show that anti-hMOR antibodies with a potential agonistic activity are commonly present in serum from healthy blood donors. Fig. 3. Inhibition of anti-hMOR antibody binding to hMOR by hMOR EL peptides. / Affinity-purified anti-hMOR IgG samples from individual healthy ...
For the TACE protein, anti-Ro/SSA Abs treatment induces the appearance of a TACE processed form devoid of the prodomain (80 kDa). Western blot analysis, performed with a biotinylated affinity-purified anti-human AREG antibody on SGEC lysates, allowed us to detect a band of 50 kDa corre- ...
Rapid progressive interstitial lung disease (RP-ILD) is the leading cause of anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis (anti-MDA5+DM) related death. Elevated serum B-cell activating factor (BAFF) levels have been implicated in connective tissue diseases associat...