3CLpro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV. Therefore, herein,...
The genome structure and functional modeling of SARS-CoV-2 (https://seq2fun.dcmb.med.umich.edu/COVID-19/) is shown in Fig. 2a. Structural biology studies have shown that papain-like protease (NSP3, PLpro), 3C-like protease (NSP5, 3CLpro), RNA-dependent RNA polymerase (RdRp), and ...
Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patients. FNC monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus w...
Multi-mutational SARS-CoV-2 variants can arise during the course of such persistent cases of COVID-19. No optimal, decisive strategy is currently available for patients with persistent infection that allows clinicians to sustain viral clearance, determine optimal timing to stop...
(SARS-CoV-2)1, is the causative agent of COVID-192, which has been responsible for one of the most devastating medical crisis of our time. Due to the lack of effective treatment options, the number of deaths related to COVID-19 has exceeded 3 million as of May 2021. Although the ...
Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit, vaccination stands as a practical strategy to prevent SARS-CoV-2 infection, sup
[5]. MERS-CoV emerged in 2012 in Saudi Arabia and led to an outbreak spanning 27 countries, affecting 2,574 people and 885 deaths in 3 years [6] (https://www.emro.who.int/health-topics/mers-cov/mers-outbreaks.html). SARS-CoV-2, the etiological agent of the pandemic COVID-19, ...
Currently, the main mechanism considered for the pathogenesis of COVID-19 is that SARS-CoV-2 infection triggers an imbalance in the immune regulation of the body, which generates cytokine storm and an excessive immune response stress and causes apoptosis, ultimately leads organ damage [21]. The...
Angiotensin-converting enzyme 2 (ACE2) is the main target for SARS-CoV-2 to invade the host cell4. ACE2-based therapy can be considered as a potential treatment strategy for COVID-19. At present, three antiviral drugs (Paxlovid™, Remdesivir, and Molnupiravir) have been authorized to ...
SARS-CoV-2 3C Like protease Peptidomimetic inhibitors 1. Introduction With the worldwide epidemic of Coronavirus Disease 2019 (COVID-19), the public health and economy has suffered a serious devastation [1]. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the pathogen of COVID...