We present a unique case of chondrodysplasia punctata with neonatal lupus in the setting of positive anti‐RNP antibodies and negative anti‐Ro/SSA and –La/SSB antibodies born to a mother with mixed connective tissue disease and Raynaud''s syndrome....
However, some patients with systemic lupus erythematosus (SLE) and systemic sclerosis may also test positive for anti-RNP. Antibodies to RNP-70, the 70 kDa protein of the U1-RNP complex show the highest diagnostic sensitivity for MCTD, their absence completely rules out this disease. Up to 32...
Indirect immunofluorescence using HEp-2 cells as substrate showed coarse speckled nuclear fluorescence without nucleolar staining in both of the samples positive for anti-U1RNP antibodies. In addition, the presence of anti-U1RNP antibodies in each serum sample was confirmed by immunodiffusion against ...
Twenty anti-U1-RNP-positive patients, 178 patients with DM, 135 patients with IMNM, and 132 patients with AS were included. Anti-U1-RNP-positive patients were younger (37 years) and more likely to be black (60%) than patients with AS, DM, or IMNM. Muscle weakness was a presenting ...
Both speckled antinuclear antibody (ANA) and anti-U1 ribonucleoprotein (RNP) antibody were positive, but anti-double-stranded DNA (dsDNA) antibody and anti-Smith (Sm) antibody were negative, while complement levels were normal. Renal biopsy revealed membranous glomerulonephritis (MGN) with diffuse ...
Anti-RNP antibodiesLupus nephritisKidney outcomeMortalityPositive anti-ribonucleoprotein antibodies may characterizea subgroup of patients affected bylupus nephritis with mild kidney damage, but little is known about their clinical features and long-term prognosis.#Patients were retrospectively selected from ...
Anti -Tau Rabbit pAb,ProductInformationDescriptionTaurabbitpolyclonalProteinfullnameMicrotubule-associatedproteintauSynonymsNeurofibrillarytangleprotein,Pairedhelicalfilament-tau,PHF-tau,MAPT,DDPAC,FTDP17,MAPTL,RNPTAU,PPP
Lane L: anti-U1-RNP-positive serum with equivocal titers for both antibodies in ELISA. Lanes 1 to 4 show the reference sera; lane 1, anti-PM/Scl-positive serum; lane 2, anti-MDA5-positive serum; lane 3, anti-TIF1-γ-positive serum; lane 4, anti-Mi-2-positive serum. Arrow and ...
84 Anti-U11/U12 RNP antibodies have been reported in 3.2% of patients with SSc who had no other SSc-associated autoantibodies. The presence of anti-U11/U12 RNP antibodies was associated with pulmonary fibrosis (79% of antibody positive vs 37% of antibody negative) and a 2.25-fold greater...
Eighty-two patients with systemic lupus erythematosus (SLE) were investigated for the presence and significance of serum antibodies to Extractable Nuclear Antigen (ENA) and its major components, RNP, Sm and SS-B (or Ha). The counterimmun... B Clotet,J Guardia,C Pigrau,... - 《Scandinavian...