Aripiprazoleanti-psychotic drugcancerP-gpdrug resistanceBackground/Aim: The present study was designed to identify conditions that would increase the sensitivity of resistant cancer cells to anti-mitotic drugs. Materials and Methods: Previously, we showed that KBV20C cancer cells highly resistant to ...
3Laboratório de Bioinformática Estrutural, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, ULBRA, Canoas, RS, Brazil Aim: Aripiprazole is an antipsychotic agent to treat schizophrenia, which acts through dopamine D2 partial agonism, serotonin 5-HT1A partial agonism and 5-HT2A...
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia... DA Nawwar,HF Zaki,RH Sayed - 《Inflammopharmacology》 被引量: 0发表: 2022年 Comparative efficacy and tolerability of 15 antipsychotic dru...
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Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number in schizophrenia and bipolar disorder type I, compared to healthy controls. However, it is unknown if mtDNA copy number alteration ...
Goldberg,Israel.Crystal Structures of Aripiprazole, a New Anti-psychotic Drug, and of Its Inclusion Compounds with Methanol, Ethanol and Water.《Journal of Inclusion Phenomena and Macrocyclic Chemistry》.2006,第55卷(第3-4期),第255页-261页....
Moreover, aripiprazole and sertindole increased the NRG1 and ErbB4 mRNA expression levels and PI3K, p-Akt, and mTOR protein expression levels. Interestingly, pre-injecting LY294002 abolished all the effects of the drugs. This study reveals that the antipsychotic effects of aripiprazole and sert...
The groups were matched according to age, sex, educational levels and severity of the psychotic disorder (Positive and Negative Syndrome Scale). As the primary endpoint, we evaluated OCS severity (Yale–Brown Obsessive–Compulsive Scale).ResultsOCS were significantly more prevalent and severe in ...
Moreover, aripiprazole and sertindole increased the NRG1 and ErbB4 mRNA expression levels and PI3K, p-Akt, and mTOR protein expression levels. Interestingly, pre-injecting LY294002 abolished all the effects of the drugs. This study reveals that the antipsychotic effects of aripiprazole and sert...
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in ratsAripiprazoleKetamineLY294002RatsSertindoleSchizophreniaInflammopharmacology - Schizophrenia is a common mental disorder affecting ...