产品名称:Anti PEG antibody ELISA (human IgM specific) 产品型号:EL-141-PEG-hIGM 产品展商:AffinityImmuno 产品文档:无相关文档 简单介绍 Anti PEG antibody ELISA (human IgM specific) Catalog EL-141-PEG-hIGM $599.99 Anti PEG antibody ELISA (human IgM specific)的详细介绍 ...
A single intravenous administration of PEG-OVA elicited an anti-PEG IgM response but not anti-PEG IgG response, while the administration did not elicit antibody against OVA. At 24 h postinjection of test PEG-OVA, although control mice showed 41.6% dose ...
AGP3is a first generation IgM monoclonal antibody that specifically binds to the backbone of PEG. AGP4is a higher affinity anti-PEG IgM monoclonal antibody. It works well for capture of PEGylated compounds in ELISA. rAGP6is a rat IgM monoclonal antibody that binds with the highest affinity to...
与未注射组小鼠相比,采用皮下注射的高剂量组小鼠,血浆中的 anti-LNP IgM 水平升高 10 倍,而采用肌肉注射或者静脉注射的高剂量组小鼠,血浆中的 anti-LNP 水平升高 2 倍或者 4 倍。 除了IgM,anti-LNP IgG 也被发现是静脉重复注射聚乙二醇化的脂质体时发生过敏反应的主要驱动者。3 种不同给药途径诱导产生的 I...
Formation of in vitro immune complexes between PEG-EPO and anti-PEG IgG or IgM antibodies was more obvious as antibody affinity increased. Likewise, high affinity anti-PEG antibodies produced greater accelerated blood clearance of PEG-EPO as compared to low affinity antibodies. The molar ratio of ...
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Polyethylene glycol (PEG) is a polymer routinely used to modify biologics and nanoparticles to prolong blood circulation and reduce immunogenicity of the underlying therapeutic. However, several PEGylated therapeutics induce the development of anti-PEG a
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route. Initial doses of PEG-G-CSF (6mg/kg) that were high enough to trigger production of anti-PEG IgM, did not trigger the accelerated clearance of a lower subsequent dose (0.06mg/kg) that was similar to i.v. clinical doses of PEG-G-CSF, but when the subsequent dose of PEG-G-...