B3 c wt wt ko Host wt ko wt Tumour Zscore 2 1 0 –1 –2 R: Regulation of IFNa signalling R: IFNg signalling R: Immunoregulatory interactions R: CD28 dep. Vav1 pathway R: Regulation of IFNg signalling R: NLRP3 inflammasomes R: Inflammasomes R: SIRP family interactions R: Phosph. CD3...
IFN-Is signal through a dimeric IFNAR1/IFNAR2 receptor that activates the kinases Jak1 and Tyk2 to initiate STAT1 and STAT2 phosphorylation (among other pathways) to induce expression of hundreds of IFN-I-stimulated genes (ISGs), including interferon regulatory factors (IRFs) (Lukhele et al....