Lacouture, et al., Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies, Ann. Oncol. 26 (2015) 2375-2391.Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann ...
InvivoGen offers twomurinizedmonoclonal antibodies (mAb) targeting PD-L1 (programmed cell death ligand 1), and therefore blocking the interaction with its receptor PD-1: Anti-PD-L1-mIgG1e3 (10F.9G2) InvivoFit™ features the variable region of the rat-derived clone 10F.9G2, targeting mo...
PD-L1(programmed death ligand 1)全称程序性死亡受体配体1,是PD-1(programmed cell death 1,程序性死亡受体1)的配体。PD-L1属于细胞膜上的一个跨膜蛋白,表达在T细胞、B细胞等免疫细胞以及肿瘤细胞上,研究表明当肿瘤细胞膜上的PD-L1与T细胞等免疫细胞上的PD-1结合后,肿瘤细胞发出抑制性信号,进而T细胞不能识别肿...
它通过阻断PD-1:PD-L1轴以及有条件地刺激4-1BB来重新激活抗肿瘤免疫反应。该双抗Fc没有免疫功能,它的PD-L1特异性臂对PD-L1检查点的阻断有持续活性,但4-1BB特异性臂介导的共刺激活性则严格取决于细胞之间的桥接。随后产生的4-1BB团簇向T细胞提供局部...
Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and methods of using such antibodies to restore T-cell function in T-cells exhibiting T-cell exhaustion or T-cell anergy.Wang, Cheng-iOh, Hsueh Ling JaniceYeo, Siok Ping...
抗PD-1抗体;ANTI-PD1抗体 CBNumber: CB35717157 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商14 Anti-PD1 Antibody化学性质 安全信息 Anti-PD1 Antibody性质、用途与生产工艺 描述 PD1 蛋白又称为程序性细胞死亡蛋白 1(PDCD1),由PDCD1(PD1)基因编码获得。PD-1 可与两种不同但相关的配...
Neutralizing recombinant murine/human chimeric antibody recognizing the PD-L1/PD-L2 binding region of human PD-1. This antibody does not cross-react with mouse PD-1, but does cross-react with monkey (M. fascicularis) PD-1. It has not been tested with oth
免疫原:重组犬PD-L1-Ig融合蛋白 报告应用: 体外PD-L1阻断 功能性实验 西方印迹 流式细胞术 配方:PBS, pH 7.0 不含稳定剂或防腐剂 内毒素:<2EU/mg (<0.002EU/μg) 通过LAL凝胶凝集试验测定 纯度:>95% 通过SDS-PAGE测定 无菌:0.2 μm过滤
艾美捷InVivoMAb anti-canine PD-L1 (B7-H1)/InvivoMAb抗犬PD-L1(B7-H1): 货号:BXC-BE0390 同型对照:Mouse IgG1, κ 推荐同型对照:InVivoMAb小鼠IgG1同型对照,特异性未知 推荐稀释液:InVivoPure pH 7.0稀释液 偶联:未偶联。可提供偶联服务。
The present invention relates to antigen binding molecules, particularly antibodies, fragments and variants thereof, that bind to the programmed death-ligand 1 (PD-L1) in a pH-depen