Anti-MDA5 antibodyclinically amyopathic dermatomyositisrapidly progressive interstitial lung diseasepre-existence of disease-specific autoantibodies before onsetObjective. To determine the clinical features associated with the antimelanoma differentia-ion-associated gene 5 antibody (anti-MDA5) in US patients ...
The myositis profile revealed anti-MDA5 positivity at significant intensity ( ++). Ferritin of 1655 ng/mL suggested a poor prognosis for anti-MDA5 DM-associated ILD. The patient was diagnosed with MDA5 antibody-associated clinically amyopathic dermatomyositis, with hyperferritinemia indicating a ...
MDA5: Melanoma differentiation-associated gene 5 MSA: Myositis-specific antibody NLR: Neutrophil-to-lymphocyte ratio RPILD: Rapidly progressive interstitial lung disease WBC: White blood cell count CTX: Cyclophosphamide CsA: Cyclosporin A Tac: Tacrolimus IVIG: Intravenous immune globulin ...
dermatomyositis anti-MDA5 antibody anti-CCP antibody rheumatoid arthritis interstitial lung disease Introduction Dermatomyositis (DM) is a type of idiopathic inflammatory myopathy (IIM) that primarily affects the skin, muscles, and lungs. Different myositis-specific antibodies represent different clinical subt...
Although the anti-MDA5 antibody levels tended to decrease (Fig. 4A) and there was no worsening of myositis, we judged that this was another exacerbation of interstitial pneumonia complicated by anti-MDA5 antibody-positive dermatomyositis. Hence, we treated the patient with an increased dose of ...
Diagnosis occurred through hospital-affiliated rheumatologist or dermatologist (16 [94%]); median (IQR) time from specialist consultation to anti-MDA5 antibody order was 1 (0-7) day. Only 2 patients had serological tests ordered before seeing a dermatologist or rheumatologist; only 1 wa...
Key words: Anti-melanoma differentiation-associated gene 5(MDA5) antibody Juvenile dermatomyositis(JDM) Clinical feature Treatment Follow-up参考文献(共24条): [1] Tansley SL, Simou S, Shaddick G, et al. Autoantibodies in juvenile-onset myositis: their diagnostic value and associated clinical phenoty...
In this case-based review, we highlight the challenges in managing a case of seropositive RA complicated by the coexistence of anti-MDA5 antibody. This review additionally examines the pathophysiology, clinical presentation, diagnosis, therapy, and prognosis of RA-ILD along with that of anti-MDA...
Diagnosis occurred through hospital-affiliated rheumatologist or dermatologist (16 [94%]); median (IQR) time from specialist consultation to anti-MDA5 antibody order was 1 (0-7) day. Only 2 patients had serological tests ordered before seeing a dermatologist or rheumatologist; only 1 was ...
The panel of myositis-associated autoantibodies and myositis-specific autoantibodies screened for this patients included anti-Mi-2α, anti-Mi-2β, anti-TIF1γ, anti-MDA5, anti-NXP2, anti-SAE1, anti-Ku, anti-PM-Scl100, anti-PM-Scl75, anti-Jo-1, anti-SRP, anti-PL-7, anti-PL-12, ...