Blood tests revealed microcytic anaemia (Hb 83 g/l, MCV 69fl), thrombocytosis, hypoalbuminemia (15 g/l), CRP 26 mg/l, elevated procalcitonin (1.46 ug/l), elevated LDH 263U/l. She had a positive double-stranded DNA and anti-cardiolipin IgM. ANCA was moderately positive with an anti-...
All patients were HLA class I genotyped to determine eligibility for CD8 T cell specific MCPyV-tetramer screening (Bloodworks Northwest, Seattle, WA). PBMC collected from patients with HLA class I (HLA-I) types that corresponded to available MCPyV-specific tetramers (A*02:01, A*24:02, B...
The red blood cell distribution width (RDW), a simple index in peripheral blood circulation, reflects the size heterogeneity of red blood cells, commonly used for differential diagnosis of anemia [26]. Several studies have demonstrated that elevated RDW is correlated with inflammatory status in vario...
First, Evidence for immune activation in IPF pathogenesis is supported by the recent identification of a signature of 52 genes expressed by peripheral blood mononuclear cells significantly associated with transplant-free survival in IPF patients [9,10]. Decreased expression of genes belonging to the ...
Serum glucose in a blood sample from the tail vein was measured using a glucometer at 60 min. The data are expressed as the means ± standard error of mean (SEM). Statistical comparisons were performed using a one-way ANOVA followed by the Student-Newman-Keuls test, and the differences ...
Moreover, since the commercial anti-CCP ELISA kit uses an even more stringent cut-off, corresponding to the 99th centile among 260 blood donors and the 98th centile among 521 disease controls, this actually strengthens the differences observed between anti-CCP antibodies and the ACPA fine ...
EDX and treatment response differences of three different types of neuropathies17. Recent data has shown that the blood nerve barrier (BNB) is also subject to contrasting changes in the three neuropathies. The inflammatory process in CIDP and in d-CIDP leads to disruption of the tight junctions ...
(Fig.1A). It was then reported that peripheral blood plasmacytoid monocytes can differentiate into dendritic cells under the influence of stimuli, such as viruses, IL-3, and CD40L [34,35,36,37]. Through isolation and in vitro studies, pDCs were identified as Natural Interferon Producing Cells...
The level of anti-α-Enolase antibodies was nearly doubled in serum of ATAB-positive patients compared to ATAB-negative patients (7·04 ± 1·80 vs 3·68 ± 0·54 ng/ml, P = 0·007, student's t-test, Fig. 7a). Additionally, the level of anti-MCV antibodies ...
(n = 3 mice). n.s., P > 0.05. RBC red blood cells, Hct hematocrit, Lym lymphocytes, Neu neutrophils, WBC white blood cells, Mon monocytes, Hgb hemoglobin, Eos eosinophils, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, ...