Both anti-IL17 and anti-IL23 appeared to be effective on scalp psoriasis; in particular patients treated with anti-IL17 drugs reached a faster significant reduction of the lesions; on the other hand, anti-IL23 monoclonal antibodies were slightly superior in maintaining the clinical improvement ...
Anti-IL-23 and anti-IL-17 drugs for the treatment of non-pustular palmoplantar psoriasis: a real-life retrospective study Luciano IbbaLuigi GargiuloAngela AlfanoRuggero Cascio IngurgioAlessandra NarcisiAntonio CostanzoMario Valenti
6. The fusion protein according to claim 1, wherein the anti-IL-17 antibody is an anti-human IL-17 antibody, preferably an anti-human IL-17A antibody; the light chain type of the antibody is κ type or λ type, preferably κ type; the anti-IL-17 antibody is preferably an IgG class...
CONCLUSION: The anti-IL-17 agents demonstrated a rapid and robust clinical improvement accompanied by a favorable short-term safety profile. The results of the phase III trials continue to reinforce the theory that the IL-17 pathway is an essential target in psoriasis treatment. J Drugs Dermatol....
andCD83and decreasing IL-10 and IL-12cytokine secretion(Piemontiet al.1999; Toebaket al.2008). Similarly,Hacksteinet al.(2001)recently reported that therapeutic doses of aspirin were potent inhibitors of mouse BMDC maturation.Antiproliferative drugsused to decreaseallograft rejectionby suppressing the...
K., Escargueil, A. E. & Skladanowski, A. Catalytic topoisomerase II inhibitors in cancer therapy. Pharmacol. Ther. 99, 167–181 (2003). Article CAS Google Scholar Chang, H. W. et al. Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins. Sci. Adv. 4, eaav...
Postoperative pain relief is crucial for full recovery. With the ongoing opioid epidemic and the insufficient effect of acetaminophen on severe pain; non-steroidal anti-inflammatory drugs (NSAIDs) are heavily used to alleviate this pain. However, NSAIDs
More importantly, açaí byproducts may be a new source of compounds with strong anti-inflammatory potential to be further explored for the development of drugs, cosmetic formulations, and/or even to be incorporated into functional foods. 3.4. Antimicrobial Activity As shown in Table 3, the ...
4.1 New drugs During the past decades new impetus has been given to antileishmanial drug discovery by advances in biology, biochemistry, parasite genomics, bioinformatics and a number of networks, partnerships and consortia working to support the development of new antileishmanial agents. Currently...
Furthermore, a possible protective effect of the anti-inflammatory drugs ketoprofen (KP) and dexamethasone (DEX) on DOX-induced cardiotoxicity in comparison to the protective effect of monoHER was investigated in this model. Materials and methods Chemicals 7-Monohydroxyethylrutoside was kindly provided...