Lebrikizumab: a new anti-IL-13 agent for treating moderate-to-severe atopic dermatitisdoi:10.1080/14712598.2024.2435427Atopic dermatitisbiologicsefficacyinterleukin-13lebrikizumabpatient profilesafetyIntroduction Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Moderate-to-severe AD ...
Anti-Human IL-4R Monoclonal Antibody(Dupilumab) 度匹鲁单抗,仅用于工业应用或科学研究,不可用于人类或动物的临床诊断或治疗,非药用. Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 s
IL-4, IL-5, IL-13, andeotaxinlevels in the bronchoalveolar lavage fluid (BALF), as well as lung tissueeosinophiliaand airway mucus production, which are recognized as important clinical hallmarks in asthma patients. Meanwhile, the transcription levels of E-selectin, IL-17, IL-33, and Muc5ac...
Size effects of polystyrene nanoparticles on atopic dermatitis-like skin lesions in NC/NGA mice. Int J Immunopathol Pharmacol. 2010;23(1):131–41. CAS Google Scholar Ilves M, Palomäki J, Vippola M, Lehto M, Savolainen K, Savinko T, Alenius H. Topically applied ZnO nanoparticles ...
IL-17 promotes angiogenesis22,23 and enhances the angiogenic activity of several chemokines.23 Basophils have been implicated in the pathogenesis of chronic urticaria,56-58 atopic dermatitis,59 systemic sclerosis,60 and lupus.61 Human basophils express VEGF-A and VEGF-B and supernatants of activated...
food allergies, and atopic dermatitis. Additional information: Clone REA210 displays negligible binding to Fc receptors. Alternative names IL-4 Stat, STAT6B, STAT6C Technical specifications
IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites, as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. Additional information: Clone REA210 displays negligible binding to Fc receptors. Alternative names IL-4 Stat...
Dupilumab is a human monoclonal antibody targeting the interleukin-4 receptor (IL-4R) alpha subunit to block interleukin-4 (IL-4)/IL-13 signaling and to inhibit the inflammatory response that plays a role in the development of atopic dermatitis [70]. IgE-targeting is highly promising for the...
A number of genetic polymorphisms in the IL-13 gene have also been linked to allergic diseases. In particular, a variant of the IL-13 gene in which the arginine residue at amino acid 130 is substituted with glutamine (Q130R) has been associated with bronchial asthma, atopic dermatitis and r...
The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic...