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SREBP target genes (LDLR, FASN, HMGCR) were either enhanced significantly or had an increased trend in HPS1 knockout cells (Supplementary Fig. 7d). However, the differences appear to be marginal and SREBP may not account for all lipid metabolism changes. In line with previous findings that ...
Further assays for the assessment of M-Protein levels include, but are not limited to immunofixation electrophoresis (IFE), serum free light chain (sFLC) assay and total protein determination (Keren D F and Schroeder L, Clin Chem Lab Med. 2016 Jun. 1; 54(6):947-61). In addition, an ...
Direct inhibition of either HMGCR or any of the numerous downstream enzymes was as efficient in reverting their malignant invasive phenotype as was knockdown of mutp53 which caused downregulation of the enzymatic cascade29. Mechanistically, mutp53 is recruited to promoters of mevalonate pathway enzymes ...
The accuracy of the anti-mitochondrial antibody and the M2 subtype test for diagnosis of primary biliary cirrhosis: a meta-analysis Clin Chem Lab Med, 52 (11) (2014), pp. 1533-1542 View in ScopusGoogle Scholar [19] H. Linklater, N. Pipitone, M.R. Rose, F. Norwood, R. Campbell, ...
24 CALM1 60 HMGCR 96 PCSK9 131 SYK 25 CAMK4 61 HSD11B1 97 PIK3R1 132 TERT 26 CASP3 62 HSP90AA1 98 PLA2G2A 133 THRB 27 CASP8 63 HTR2A 99 PLAT 134 TLR9 28 CCNA2 64 HTR2C 100 PLAU 135 TP53 29 CDK1 65 IDE 101 PLG 136 TTR 30 CDK5R1 66 IGF1R 102 POLB 137 TYR 31 CDKN1A ...
S2). On the other hand, HMGCR and ACAT2 mRNA levels were not significantly different compared with the model control rats. LCAT, CYP7A1 and LDLR protein expression in HCD-fed rats treated with ERMO increased compared with the model control rats (Fig. 1). HCD-fed rats treated with ERMO ...
(SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)) and upregulating those for β-oxidation (peroxisome proliferator-activated receptor alpha (PPAR-α) and carnitine palmitoyltransferase 1 (CPT1)) and synthesis of bile acid (cytochrome P450 family 7 subfamily A member 1 (CYP7A1)) (...
Dietary extra-virgin olive oil polyphenols do not attenuate colon inflammation in transgenic HLAB-27 rats but exert hypocholesterolemic effects through the modulation of HMGCR and PPAR-α gene expression in the liver. Lifestyle Genom. 2019, 11, 99–108. [Google Scholar] [CrossRef] [PubMed] ...