ANTI-HIV DRUGSShozo SHOJI
非甾体抗炎药(NSAIDs) (Non-Steroid Anti-Inflammatory Drugs) 研究进展 简 述 人类使用非甾体抗炎药( nonsteroidal anti-inflammatory drugs , NSAIDs)已有100多年的历史; 全球每天约有3千万人使用NSAIDs,仅美国每年就有7～10亿张NSAIDs处方。在国内,NSAIDs销量仅次于抗感染药,位居第二; NSAIDs致不良反应的发...
传统NSAIDs消化道并发症的死亡人数=HIV死亡人数;作用机制: 现在使用的NSAID;对脂氧酶的影响 ;环氧化酶-2 (COX-2) 的发现; 花生四烯酸; 花生四烯酸;NSAIDs对COX-1和 COX-2不同作用如下图所示 ;塞来昔布选择性抑制COX-2,消化道安全性更好2 ;手术创伤导致COX-2表达增加;正常疼痛感受曲线;1.Samad TA, ...
In Vol 1 No 4 of this journal we carried reviews of articles on HIV/AIDS that had appeared in two United States publications. Both these articles reported on forthcoming new guidelines on the use of anti-HIV drugs that the US government would issue. These were issued on February 5, this ...
Mitochondria HIV AIDS Mitochondrial DNA Antiretroviral therapy HAART 1. Introduction Potent antiretroviral drugs can prolong for extremely long periods the course of the infection with the human immunodeficiency virus (HIV), the cause of the acquired immunodeficiency syndrome (AIDS). According to the Join...
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV In 2008, 25 years after the human immunodeficiency virus (HIV) was discovered as the then tentative aetiological agent of acquired immune deficiency syndro...
Chow WA, Jiang C, Guan M: Anti-HIV drugs for cancer therapeutics: back to the future? The Lancet Oncology 2009, 10(1):61-71.Chow WA, Jiang C, Guan M (2009) Anti-HIV drugs for cancer therapeutics: back to the future? Lancet Oncol 10(1):61-71...
Pharmacogenetics of Anti-HIV Drugs Pharmacogenetics holds promise in HIV treatment because of the complexity and potential toxicity of multidrug therapies that are prescribed for long period... A Telenti,UM Zanger - 《Annu Rev Pharmacol Toxicol》 被引量: 171发表: 2008年 Hepatic and Intestinal Drug...
However, the advent of Highly Active Anti-Retroviral Therapy (HAART), a combination of drugs that inhibit HIV-1 replication, has led to reduced viremia and the onset of opportunistic infections in most patients and prolonged survival. Chemotherapy has been the main mode of treatment of AIDS. ...
Drug treatment, an integral part in creating this improvement in life expectancy, consists of antiretroviral drugs, drugs that treat and prevent opportunistic diseases, and therapies that treat specific symptoms of AIDS, such as wasting or anemia. Five available drugs for treating HIV are AZT (...