(TNF-伪, IL-1尾, and IL-6) in plasma and lung tissue after LPS injection were ameliorated by SSV mAb.SSV mAb is shown to have anti-inflammatory activity and organ-protective effects, highlighting the importance of controlling histone H1 as well as H3 and H4 levels during inflammation.Toru...
Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 52, 237–268 (2000). CAS PubMed Google Scholar Rahma, O. E. & Hodi, F. S. The intersection between tumor angiogenesis and immune suppression. ...
Anti-dsDNA antibodies are often associated with inflammation and tissue damage. The antibodies bind to nucleosomes, which consist of DNA enveloped by histone proteins (H2A, H2B, H3, and H4). H1 histone proteins function to excrete nucleosomes during apoptosis. Failure of uptake of cells ...
but are also a way of controlling immunity and inflammation. Metabolic reprogramming of immune cells is essential for both inflammatory as well as anti-inflammatory responses. Four anti-inflammatory therapies, DMF, Metformin
Importantly, transcriptional analysis of fluorescence-activated cell sorting (FACS) sorted splenic DC subsets from H1ΔMx mice confirmed the absence of Hdac1 expression in DC populations in vivo (Figure S1K). Additionally, by intracellular FACS, total histone 3 lysine 27 acetylation (H3K27Ac) was...
Molès JP, Griez A, Guilhou JJ, Girard C, Nagot N, Van de Perre P, Dujols P. Cytosolic RNA:DNA Duplexes Generated by Endogenous Reverse Transcriptase Activity as Autonomous Inducers of Skin Inflammation in Psoriasis. PLoS One. 2017 Jan 17;12(1):e0169879. doi: 10.1371/journal.pone.016...
D Heatmap showing the significantly altered inflammation-related genes after CacyBP or Myd88 knockdown in HCC cells. The font color of chemokines is in red. E–G mRNA expression of CX3CL1 (E), CCL15 (F) or CCL14 (G) after CacyBP or Myd88 depletion in HCC cells. H Expression of ...
Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the...
High-fat diet (HFD) resulted in a tremendous increase in lung inflammation and fibrotic changes in the lung tissues of Sohlh2 CKI mice. Sohlh2 overexpression led to a significant rise of intracellular ROS and apoptosis in the lung, mouse primary AECIIs, and human A549 cells, which was ...
et al. Immunogenic cell death and its therapeutic or prognostic potential in high-grade glioma. Genes. Immun. 23, 1–11 (2022). Article PubMed PubMed Central Google Scholar Rufo, N. et al. Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1alpha kinase ...