Anticancer combination comprises a mitotic inhibitor and a MEK inhibitor. ACTIVITY : Cytostatic. MECHANISM OF ACTION : MEK inhibitor; mitotic inhibitor. In a cell culture assay using HT-29 colon carcinoma cells, paclitaxel and 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro...
Toxicity data will be presented at the meeting.Conclusions:Our results suggest no significant differences in outcomes between adjuvant BRAF/MEKi and anti-PD-1 treatment in stage III melanoma.1- and 2-year RFS, DMFS, and OS rates for BRAF/MEK inhibitors and anti-PD-1 in the unmatched cohort...
Discrepancies in our practices of antibiotic prophylaxis in urology have been observed, leading to the development of a local protocol in line with international recommendations and ensure its dissemination and application.doi:10.1016/j.afju.2018.01.003kartouti, A. El...
Syndrome de BrugadaTrametinibMonoclonal antibodies targeted against the immune checkpoint molecules CTLA-4 and PD-1 have recently obtained approval for the treatment of metastatic melanoma and advanced/refractory non small-cell lung cancers and metastatic renal cancer. Besides their efficacy profile, these...
Johann De BonoTolcher AW, Khan K, Ong M, Banerji U, Papadimitrakopoulou V, Gandara DR, et al. Anti-tumour activity in RAS-driven tumours by blocking AKT and MEK. Clin Cancer Res. 2014.Tolcher AW, Khan K, Ong M, Banerji U, Papadimitrakopoulou V, Gandara DR, et al. Anti-tumour ...
Mohammad-Ali Jenabian, Cecilia T Costiniuk, Ralph-Sydney Mboumba Bouassa, Linda Chapdeleine Mekue Mouafo, Thomas V Brogan, Laurent Bélec. (2015) Tackling virological failure in HIV-infected children living in Africa. Expert Review of Anti-infective Therapy 13 , 1213-1223 /...
2015, 16 21355 3D1 (60 µL) in HBS-EP at increasing concentrations (6–100 nM). A 10 mM NaOH solution was used to regenerate the chip surface. After the single-dose screening, dose-dependent binding analyses were carried out with the two antibodies, 3D1 and 5F10, able to bind the...
The Croatian samples appeared to have better biological properties and are therefore good candidates for applications as preservatives or antiageing agents.doi:10.3390/foods13050695Olivera PoliteoPavao urlinPetra BrzoviKillian AuzendeChristian MagnéIvana Generali MekiniFoods...
Adjuvant BRAF/MEK versus anti-PD-1 in BRAF-mutant melanoma: a propensity score matched survival and safety analysisdoi:10.1016/j.ejso.2024.109328M. BloemM. de MezaM. AartsF. van den BerkmortelC. BlankM. Boers-SonderenH. Bonenkamp
IK-595 is a novel MEK-RAF molecular glue that prolongs pathway inhibition, minimizing the potential for resistance, while providing an optimal therapeutic window for patients with RAS/RAF-driven cancer.Eric HainesRachel CatterallVictor De Jesus