Anti-HAVPositive103331033 Co-infectedCMV/EBV/HSV101111011 Anti-HDVPositive9888999 Anti-T.pallidumPositive102221022 Non-viralHepatitis100001000 RheumatoidFactorPositive100001000 Anti-dsDNAPositive100001000 PregnantFemales140001400 MultiparousFemales100001000 HyperIgG/IgM9333633 ...
The germline encoding of a non-immune immunoglobulin M (IgM) molecule in mammals was experimentally documented for the first time as a result of the specifically timed ovariectomy of C57BL/10 mice. The target of this innate antibody involves a trans-species developmental antigen that...
Autoimmune hemolytic anemia due to warm reactive IgM autoantibodies is unusual, severe, and often fails to respond to standard immunosuppressive therapies in both adults and children. A 6-year-old girl with common variable immunodeficiency had longstanding steroid dependent, splenectomy-unresponsive, warm...
Successful anti-CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM autoantibody in a child with common varia... ( 2004 ). Successful anti-CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM autoantibody in a ...
(a). End point titers of different isotypes (IgA (b) and IgM (c)) and subclasses (IgG1 (d), IgG2b (e), and IgG3 (f)) of immunoglobulins against RBD were determined by ELISA six weeks after the first immunization. Graphs represent the mean EPT of groups of mice (n= 5 per ...
During evolution, B-1 CD5+ cells acquired the ability to switch from polymeric IgM to monomeric IgG-type antibodies, thus allowing the production of polyreactive and mono-reactive IgG antibodies against either self- or non-self-antigens, mainly produced by B-2 cells [26]. The humoral innate...
T-cell immunoglobulin domain and mucin domain 3 (Tim-3, HAVCR2, or CD366) is a 33 KD type I transmembrane glycoprotein, a member of the T-cell Immunoglobulin- and mucin-domain-containing family that plays an important role in promoting T-cell exhaustion in both chronic viral infections and...
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Serum levels of anti-idiotypic IgM autoAbs reactive with hypocretin-1 IgG autoAbs in subjects with central hypersomnia and controls.Aude DeloumeauSophie BayardQuentin CoquerelPierre DéchelotteChristine BoleFeysotBertrand CarlanderValérie Cochen De Co...
This cross-reactivity was mainly a property of monoclonal alloantibodies belonging to the IgM isotype (among the 49 cross-reacting Mabs, 37 were IgM). The results confirm that during an immune response against a foreign antigen (alloantigen), B cells that produce polyreactive antibodies are not...