In contrast, GPC3-negative SK-HEP-1 cells (0.57卤0.16%) and blocked Hep3B cells (0.81卤0.06%) exhibited significantly lower uptake at the same time point. ImmunoPET imaging illustrated rapid accumulation of [68Ga]Ga-NOTA-aGPC3-scFv in Hep3B xenografts, reaching 3.00 卤 1.37 %ID/g at 1...
To assess the efficacy of GPC3-targeting CAR-NK cells for HCC cells, a CAR construct with anti-GPC3 scFv sequence was generated (Fig. 1B), based on previously reported CAR backbone containing CD8α hinge, NKG2D transmembrane domain, 2B4 co-stimulatory domain and CD3ζ activation domain, follow...
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Adoptive cell therapy (ACT) is a particularly promising area of cancer immunotherapy [1,2,3]. Unlike T cells, NK cells play an important role in immune surveillance by targeting tumor cells that downregulate HLA class I molecules or express stress markers [4]. Engineered T and NK cells that...
13.在一个优选实施方案中,所述基于anti-cd3的双特异性t细胞激活元件是融合蛋白,所述融合蛋白包含一个或多个肿瘤抗原识别结构域和一个或多个抗cd3抗体片段,例如靶向cd3的单域抗体序列(vhh)、单链抗体可变区序列(scfv)和/或抗原结合片段(fab)。在 protein)以顺式或融合形式表达,所述能够作为安全开关的蛋白包括诱导...
CD3 & GPC3 CD3 & GPNMB CD3 & HBVgp3 CD3 & HER2 CD3 & HIV-1 gp120 CD3 & HIV-1 gp41 CD3 & HN CD3 & IGF1R CD3 & IL2R CD3 & Met CD3 & MUC1 CD3 & p97 CD3 & P-Cadherin CD3 & PD1 CD3 & PLAP CD3 & PSA CD3 & PSCA ...
Engineered Anti-GPC3 Immunotoxin, HN3-ABD-T20, produces regression in Mouse Liver Cancer xenografts through prolonged serum Retention. Hepatology. 2020;71(5):1696–711. Article PubMed Google Scholar Tanyi JL, et al. Possible compartmental cytokine release syndrome in a patient with recurrent ...
product information Antigen : IFN-gamma Apps. Abbrev. : ICFC Cat # : 502527 Clone : 4S.B3 Item : PE/Cyanine7 anti-human IFN-γ Isotype : Mouse IgG1, κ Other Names : Interferon-γ, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF), IFN-g, ...
The Fd fragment and LC from an anti-BCMA antibody are both extended with the scFv fragment from an anti-CD3 antibody This BsAb can retarget T cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy. Datasheet INQUIRY Specifications Targets BCMA & CD3 ...
CD3 & GPC3 CD3 & GPNMB CD3 & HBVgp3 CD3 & HER2 CD3 & HIV-1 gp120 CD3 & HIV-1 gp41 CD3 & HN CD3 & IGF1R CD3 & IL2R CD3 & Met CD3 & MUC1 CD3 & p97 CD3 & P-Cadherin CD3 & PD1 CD3 & PLAP CD3 & PSA CD3 & PSCA ...