Beyond understanding the mechanisms of drug resistance, the continual discovery of next generation drugs safer for children and easier to administer, the discovery of predictive biomarkers to avoid futility should ease the acceptance by patient, health care professionals and regulatory agenc...
This synergy is driven by two GD2-specific factors that reorient the balance of macrophage activity. Ligation of GD2 on tumor cells (a) causes upregulation of surface calreticulin, a pro-phagocytic ‘Eat me’ signal that primes cells for removal and (b) interrupts the interaction of GD2 with...
(2009). “The GD2-specific 14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells.” Cancer Lett 281(2): 171-182. in vitro induction of apoptosis in GD2+ c...
第二, RABV在感染机体后并不能引起足够的天然免疫反应来反抗病毒, 所以狂犬病在潜伏期缺乏明显的症状, 阻碍狂犬病早期诊断也成为狂犬病高度致死的原因之一。第三, RABV可以被狂犬病毒抗体中和, 但是有效的抗体无法通过血脑屏障(Blood-brain barrier, BBB)进入中枢神经系统, 这也是狂犬病致死的一大原因。第四, 当前...
Immunotherapy with the chimeric anti-GD2 monoclonal antibody dinutuximab, combined with alternating granulocyte-macrophage colony-stimulating factor and intravenous interleukin-2 (IL-2), improves survival in patients with high-risk neuroblastoma. We aimed to assess event-free survival after treatment with...
Despite improvements in survival of high-risk neuroblastoma patients after the introduction of anti-GD2 (disialoganglioside) immunotherapy, outcomes remain poor, and new therapies are needed to combat recurrent metastatic disease9. C–C motif chemokine ligand 2 (CCL2) or monocyte chemoattractant ...
NGP has minimal GD2 expression on its cell surface56. Cell lines were routinely screened for mycoplasma contamination monthly using MycoAlert (Lonza, Cat# LT07-318, Allendale, NJ, USA). Neuroblastoma cell lines were authenticated by short tandem repeat multiplex assay using the AmpFLSTR Identifiler...
Phagocytosis of RM-9 cells (a-iii) by BMDMs with anti-GD2 opsonization and/or CD47 antibody blockade. Statistical significance was assessed by one-way ANOVA with Tukey’s multiple comparisons test (mean ± s.e.m., n = 3 wells per condition). WT RM-9 tumour growth curves (a-iv...
The mitotic arrest caused by antimicrotubule drugs is associated with phosphorylation of the B-cell lymphoma (BCL2) protein and increased intracellular levels of the BCL2-associated X protein (Bax), which promote apoptosis. As natural products, overexpression of the efflux pump multidrug resistance ...
Liposomes, modified with monoclonal antibodies, are suitable carriers for targeted delivery of chemotherapeutic drugs into brain tumors. Here, we investiga... B Gupta,VP Torchilin - 《Cancer Immunology Immunotherapy》 被引量: 170发表: 2007年 Development of anti-p185IER2 immunoliposomes for The prod...