综上,Anti-(G4S)n linker(B02H1) mAb这款抗体具有如下特征: 1、通用性:是一款经验证的通用 CAR 阳性率检测试剂,它可以通过消除不必要且耗时的步骤,加快药物研发进程。 2、普适性:适用于所有靶点CAR检测 (含(G4S)n, n≥2);不同抗体类型CAR检测 (含(G4S)n, n≥2)。 3、免干扰:无惧抗原干扰,检测CA...
关键字:G4S linker;G4S linker抗体;Anti-G4S linker;ACRO;百普赛斯; 公司简介 百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、...
货号:G4S linker 是否进口:否 G4Slinker产品信息 名称:MonoclonalAnti-G4S linker Antibody 物种:Mouse 属性:Antibody 标记:PE Labeled/APC Labeled 内毒素(Endotoxin) Less than 1.0 EU per μg by the LAL method. 制剂(Formulation) Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose...
Anti-(G4S)n (B02H1) mAb这款识别广泛CAR的检测试剂可直接识别和确认CAR存在,而不管其抗原特异性。Anti-(G4S)n (B02H1) mAb 抗体通过识别(G4S)n柔性Linker,可与细胞表面表达的不同特异性 CAR 发生反应,这些 CAR 在细胞外结构域的 scFv 中包含一个 (G4S)n接头(n≥2)。
通过设计不同的linker,可产生各种形式的多聚体,如二聚体、三聚体和双特异性抗体。关于linker序列设计,最初由Huston等设计使用的15-聚体(G4S)3,是五肽GGGGS的多聚体。此后,(G4S)n接头氨基酸序列基序用作基本支架,其中18-聚体GGSSRSSSGGGGSGGGGG和20-聚体(G4S)4是一些常用的多聚体。
本发明公开了一种自分泌IL15与antiTIM3结合的融合蛋白及其应用,该融合蛋白是按照antiTIM3,G4S*4Linker,IL15N72D,G4S*4Linker和IL15RaSu顺序依次串联构建的,且所述自分泌IL15与IL15RaSu结合为超激动蛋白.并使得含有该免疫细胞成功膜表达该融合蛋白,以达成增强免疫细胞的增殖能力,抗凋亡能力和对于肿瘤的杀伤能力....
The dimeric forms were generated using 6 × (G4S) linker to connect two monomeric VHHs in tandem N terminus to C terminus orientation. Trimers were generated using two 3 × (G4S) linkers between monomeric nanobody units. The multimers were cloned into pET-26b vector adding a C-...
The dark gray boxes represent (G4S) linker peptides (L), the orange boxes represent FLAG tags (F) and the yellow boxes represent c-myc/His-6 tags (MH). The white box represents the IRES sequence from the encephalomyocarditis virus (EMCV) and the red box the 2A peptide from the FMDV....
For LAIR fusions, the murine LAIR1 gene was synthesized as a gBlock gene fragment (Integrated DNA technologies) and cloned as a fusion to the C-terminus of the heavy chain constant region separated by a flexible (G4S)3 linker. Plasmids were transformed into Stellar competent cells for ...
In one embodiment, a linker is provided between the anti-target binding moiety and the anti-SA single variant or moiety, the linker comprising the amino acid sequence AST, optionally ASTSGPS, e.g., where anti-SA and anti-target dAbs are used. Alternative linkers are described in WO2007085814...