Action mechanism of anti-wrinkle effect of Rhamnus yoshinoi methanol extract in human dermal fibroblast and keratinocyte cell linesAnti-wrinkle effectCCD-986sk cellsERK-1/2 protein phosphorylationHaCaT cellsMMP-3\\n Rhamnus yoshinoi\\nRhamnus yoshinoi is a deciduous broad-leaf bush and endemic ...
19H6-Hu in combination with trastuzumab was more effective at blocking phosphorylation of ERK1/2, AKT(S473)and HER2 (Y1248) in HER2-positive cancer cells compared to trastuzumab alone or in combination with pertuzumab. Combination of three antibodies, 19H6-Hu, inetetamab (a trastuzumab analog...
Han et al. [102] studied whether GFW has inhibitory effect on P-gp, and investigated the possible mechanism of action. Their results indicated that GFW could sensitize DDP-resistant SKOV3/DDP cells by suppressing the function of P-gp, which may be achieved by inhibiting PI3K/AKT/mTOR ...
Despite extensive research on the beneficial immunomodulatory effects of DMF and its hydrolyzed counterpart mono methyl fumarate (MMF), the exact mechanism of action for DMF has yet to be determined. DMF promotes expression of antioxidant genes by stabilizing the ubiquitously and constitutively expressed ...
MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int. Immunopharmacol. 11, 856–861 (2011). Article CAS PubMed Google Scholar Ferrara, N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev. 21, 21–26 (2010). Article CAS Pub...
Strominger JL, Tipper DJ (1965) Bacterial cell wall synthesis and structure in relation to the mechanism of action of penicillins and other antibacterial agents. Am J Med 39: 708–721 PubMed CAS Google Scholar Sunahara S, Nakagawa H (1972) Metabolic study and controlled clinical trials of ...
The anticipated mechanism of action of mandarin peel oil on scabies-infected rabbits was shown schematically in Fig.12. Infiltrating mites, based on reports, activate the skin's keratinocytes, and exhibit a capacity to suppress the immune system's response by lowering the expression of genes of ...
However, the functionally categorized heatmap blocks presented in Figure 3 are themselves only a beginning for the process of determining a mechanism of action. This preliminary analysis shows either transcript level changes that were strong in magnitude, for genes of some known functional description,...
4b). To clarify the mechanism of action of DUSP5 on regulation of NF-κB signal transduction, the phosphorylation levels of signaling kinases upstream of IκBα, including IKKα/β and TAK1, in the presence of DUSP5 was investigated. As shown in Fig. 4b, phosphorylation at Ser-176/180 ...
These results revalidated our previous findings related to the effects of IRL-1620 in the MCAO rat model and also warranted further studies to investigate the anti-apoptotic mechanism of action of IRL-1620 in the infarcted rat brains. It has been observed that ET-1 binding to endothelial cell ...