4), M802 and Herceptin treatment had no effect on the levels of p-Erk and p-Akt in JIMT-1 cells. These results thus indicate that the M802-mediated regulation of the PI3K/AKT and MAPK pathways are responsible for its effects on induction of apoptosis and cell cycle arrest. Fig. 5 ...
KTZ inhibits TDE secretion by targeting multiple pathways including the syndecan-syntenin-ALIX, Rab27, ERK1/2, and nSMase59. In C4-2B and PC-3 prostate cancer cells, KTZ led to potent tumor-specific inhibition of TDE biogenesis while showing no effect in normal prostate RPWE-1 cell line49...
KTZ inhibits TDE secretion by targeting multiple pathways including the syndecan-syntenin-ALIX, Rab27, ERK1/2, and nSMase59. In C4-2B and PC-3 prostate cancer cells, KTZ led to potent tumor-specific inhibition of TDE biogenesis while showing no effect in normal prostate RPWE-1 cell line49...
clinical trial did not mention whether or not postpartum women were included, it is unlikely that postpartum women would have a different outcome compared to other study participants regarding transfusion (Answer E). Based on this patient’s clinical history and the findings of the study, all ...
The dotted line represents the p-ERK IC90 values in cells after treatment with AMG 510 for 2 h. g, Individual CT-26 KRASG12C tumour plots of BALB/c nude mice (n = 10) treated with AMG 510 (200 mg kg−1). Source data Extended Data Fig. 5 Clinical activity of AMG 510 in ...
In neoplastic cells, the increased AMPK activity leads to downstream inhibition of PI3K/Akt/mTOR and Ras/RafMEK/ERK signaling, protein synthesis, and proliferation [51]. Metformin exerts its anti-cancer effect through the tumor suppressor protein, LKB1, mediated activation of the AMP-activated ...
Acupuncture increases the phosphorylation levels of extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus and PFC, and its antidepressant effects might be mediated through activating the ERK-CREB pathway in the brain [111]. In addition, MEK ...
In a double-blind randomized controlled clinical trial, women with advanced metastatic breast cancer received treatment with paclitaxel with placebo or paclitaxel with curcumin. The paclitaxel-curcumin combination produced a superior response compared to the placebo. Polyphenols, particularly curcumin, ...
The downstream proteins ERK, Akt and BDNF of the signalling pathways were not affected by fexagratinib at either time point (Figure 5d–g). In the suppression experiment, FGFR2 expression was up-regulated by 12.5 mg·kg−1 of fexagratinib at Day 20 p.i. BDNF expression was increased...
Even though cetuximab has no effect on RAS cell viability and ERK (extracellular-signal-regulated kinase) phosphorylation (one of the last kinases of the EGFR pathway), trametinib can induce cell death and inhibit the activation of ERK alone or in combination with cetuximab. In a more pathologic...