anti-drug antibodiesADAAdeno-associated virus (AAV) delivery of potent and broadly neutralizing antibodies (bNAbs is a promising approach for the prevention of HIV-1 infection. The immunoglobulin G(IgG)1 subtype is usually selected for this application, because it efficiently mediates antibody effector...
但是因为免疫源性强,产生人抗小鼠抗体(human anti‐murine antibodies ,HAMA), 导致快速的药物清除,半衰期只有几个小时到十几个小时,限制了临床使用。 影响抗体药物ADA(Anti-Drug antibody)产生的因素mp.weixin.qq.com/s/VZidrEghK9gCUusOKK1K4g 之后,为了降低免疫原性,先后开发了嵌合体抗体,人源化抗体和全...
Anti-drug antibody assays A validated cGLP sandwich ELISA method was used for the determination of anti-uricase IgG antibodies in human serum. Analysis was conducted at a central lab that was blinded to the treatment. Uricase (non-pegylated, 3SBio) coated on to an ELISA plate was used to ...
antibody (ˈæntɪˌbɒdɪ) n,pl-bodies (Biochemistry) any of various proteins produced in the blood in response to the presence of an antigen. By becoming attached to antigens on infectious organisms antibodies can render them harmless or cause them to be destroyed. See alsoimmunog...
antimalarial,antimalarial drug- a medicinal drug used to prevent or treat malaria medicament,medication,medicinal drug,medicine- (medicine) something that treats or prevents or alleviates the symptoms of disease Flagyl,metronidazole- antiprotozoal medication (trade name Flagyl) used to treat trichomoniasis...
[3] Wang, L.et al. Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. Sci.Transl. Med. 2020. [4] Coats, S. Antibody-drug conjugates: future directions in clinical and translational strategies to improve the therapeutic index. Clin. Cancer Res. 2019. ...
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells leading to intracellular drug release. Typically, only a subset of patients with solid tumours has sufficient expression of such a receptor, while there are suitable n
median age at disease onset, characteristic clinical features, concurrent tumor, elevated CSF white cell counts and protein levels, percentage of positive oligoclonal bands and positive CSF DPPX antibody, non-specific brain MRI changes and response to acute-stage treatment, relapse or motality rate ...
antibody (ˈæntɪˌbɒdɪ) n,pl-bodies (Biochemistry) any of various proteins produced in the blood in response to the presence of an antigen. By becoming attached to antigens on infectious organisms antibodies can render them harmless or cause them to be destroyed. See alsoimmunog...
抗人胸腺细胞免疫球蛋白: 一种胸腺细胞抑制剂药物,由Genzyme Corp. (Genzyme Corp.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: 胸腺细胞抑制剂,治疗领域: 免疫系统疾病,血液及淋巴系统疾病,其他疾病,在研适应症: 器官移植排斥,移植物抗宿主病,再生障