PROBLEM TO BE SOLVED: To obtain a novel vitamin D derivative that is useful as a therapeutic agent for hypercalcemia due to excessive vitamin D.MIURA DAISHIROU三浦 大志郎ISHIZUKA SEIICHI石塚 誠一OSONO KEIICHI大薗 恵一MANABE KENJI真鍋 健次...
b. brucei murine model proved 32 to be the most potent lead-compound in this series and established one more active derivative 33. Treatment with 32 and 33 (50 mg/kg, i.p.) cured 100% of mice [76]. 4.5 Agents based on other heterocycles...
The DNA binding ability with[Zn(IP)(H2O)]was evaluated by monitoring changes in DNA gel electrophoresis-induced binding by gradual increasing concentration of[Zn(IP)(H2O)]. The concentration range was 5–25 µg/mL in a buffer solution containing 20 mM Tris HCl and 50 mM NaCl at pH 7.3...
Aminoglutethimide, an amino derivative of the hypnotic glutethimide, is of particular interest in this context for its effects on the adrenal have been well characterized and represent a typical form of lipid or lipoid hyperplasia. Its effects on the endocrine system were first described in man...
The (R)-MTPA derivative [(−)-1b, 1.3 mg] was obtained using (S)-MTPA chloride and chromatographed in the same manner. A similar procedure was applied to yield the MTPA esters of compounds (−)-2 [(−)-2a and (−)-2b]. (±)-Japonone A [(±...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See ourprivacy policyfor more information on the use of your personal...
The o-toluamides 5 were deprotonated using n-BuLi and reacted with the 2-aminobenzonitriles 6 to give the 3-arylisoquinolones 7. Finally, intramolecular cyclization was performed using diiodomethane reduced with lithium aluminium hydride to give the dihydro derivative 9an(dScKh2eCmOe3Sa2s)b. ...
60309932-hydroxypropionic acid derivative and its manufacturing method2000-02-29Jew et al. 5468490Lipidic furans useful for skin therapeutics1995-11-21Huber et al. 5262163Process for preparing the nonsaponifiable matter of avocado enabling in one of its fractions termed H to be improved1993-11-16Ra...
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. Biochem. Biophys. Res. Commun. 1989, 165, 1375–1381. [Google Scholar] Tanaka, H.; Hirayama, M.; Suzuki, M.; Miyasaka, T.; Matsuda, A.; Ueda, T. A lithiation route to...
Spiro[oxazoline-3,3′-oxindole] derivative SPX-F (Figure 1) has demonstrated an anti-inflammatory potency and promising antipyretic activity [25]. Spirooxindole-pyrrolothiazole IVc (Figure 1) has shown potent anti-inflammatory efficacy with an IC50 = 2.4 ± 1.3 μM and was found to be ...