【产品介绍】细胞角蛋白3抗体Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly.细胞角蛋白3抗体API5 expression is often upregulated in tumor cells, particularly in metastatic cells. It is a critical determinant of E2F1-induced apoptosis, acting downstr...
Recently, human IP-10 has also been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent anti-tumor effect. A chemokine receptor specific for IP-10 and MIG (CXCR3) has been cloned and shown to be highly expre...
c, ATAC-seq signal of Cxcr3 in representative regions showing differentially accessible status across different cell types. d, Number of CD8+ T cells in the BM of WT and CXCR3-KO mice (n = 5 or 6 per group). e, Number of total BM cells and GFP+ leukemic cells in the BM of WT+...
Indeed, treatment of HPS1 knockout HAP1 cells with the mTORC1 inhibitor rapamycin restored anti-microbial activity (Fig. 5h). We validated this finding in HPS-1 patient monocyte-derived macrophages and showed that rapamycin also rescued the bacterial handling defect in patient cells (Fig. 5i)....
3D). These results showed that pretreating HCC cells with irradiation could enhance in vitro cytotoxic effect and migration activity of CXCR2-armed CAR-NK92 cells (p < 0.05) but not GFP-expressing CAR-NK92 cells (p > 0.05). Fig. 3 The effect of pretreating of HCC cells with...
SEA625Ra大鼠趋化因子C-X-C-基元受体3(CXCR3)ELISA试剂盒ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) SEA778Ra大鼠B-细胞淋巴瘤因子2(Bcl2)ELISA试剂盒ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) SEA626Ra大鼠胱天蛋白酶3(CASP3)ELISA试剂盒ELISA Kit for Caspase 3 (CASP3) ...
Recombinant Human Interleukin-15 and Anti-PD-L1 Combination Therapy Expands a CXCR3(+)PD1(-/low) CD8 T-Cell Subset in Simian Immunodeficiency Virus-Infected Rhesus Macaquesanti-PD-L1checkpoint inhibitorHIVSIV infectionIL-15Background: The PD1/PD-L1 pathway contributes to the pathogenesis of human...
Etoposide (VP-16) is a topoisomerase II inhibitor that is used extensively as a cytotoxic agent in standard chemotherapy regimens for neuroblastoma and has been previously established for concomitant therapy in the evaluation of novel therapies for neuroblastoma both in xenograft preclinical experiments ...
CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy. Cancer Treat Rev. 2018;63:40–47. Article CAS PubMed Google Scholar Kim CW, Kim KD, Lee HK. The role of dendritic cells in tumor microenvironments and their uses as therapeutic targets. BMB...
Findings of qRT-PCR and western blotting showed that PD-L1 was upregulated in H1299 and H1975 cells overexpressing ALKBH5, whereas the addition of the JAK2/p-STAT3 inhibitor, AG490, attenuated this increase (Fig. 4A and B). Subsequent CCK-8 and colony formation assays showed significant incr...