Animals were then euthanized, and biochemical parameters of oxidative stress, inflammation, and apoptosis were analyzed in the hippocampus and prefrontal cortex. Results. On the 4th day of the acquisition phase in the Morris water maze, Z. jujuba (29 and 114 mg/kg) reduce...
The molecular mechanisms of excitation/inhibition imbalances promoting seizure generation in epilepsy patients are not fully understood. Evidence suggests that Pannexin1 (Panx1), an ATP release channel, modulates the excitability of the brain. In this report, we performed electrophysiological, behavioral, ...
[IF=3.44]Chen B et al. Inhibition of Connexin43 Hemichannels with Gap19 Protect-s Cerebral Ischemia/Reperfusion Injury via the JAK2/STAT3 Pathway in Mice.(2018) Brain Res Bull.WB ; Mouse. PubMed:30593877 [IF=3.412]Yang Q et al. Activation of Nrf2 by phloretin attenuates palmitic acid-ind...
The molecular mechanisms of excitation/inhibition imbalances promoting seizure generation in epilepsy patients are not fully understood. Evidence suggests that Pannexin1 (Panx1), an ATP release channel, modulates the excitability of the brain. In this report, we performed electrophysiological, behavioral, ...
2. The arrestment of cell cycle via the modulation of cell cycle regulatory proteins 3. The alteration of mitochondrial function 4. The Inhibition of the activity of sex steroid hormones 5. The regulation of insulin-like growth factors (IGFs) system 6. The modification of relevant gene expressi...
Ni X, Zhang L, Ma X, Shan L, Li L, Si J, et al.β‑estradiol alleviates hypertension‑ and concanavalin A‑mediated inflammatory responses via modulation of connexins in peripheral blood lymphocytes. Mol Med Rep. 2019;19:3743-3755 pubmed publisher Durgeau A, Virk Y, Gros G, Voi...
Researchers investigating the anti-inflammatory properties of naturally occurring compounds can use various in vitro models of immune modulation. THP-1 human leukemia monocytic cells that can be differentiated into THP-1 derived macrophages are commonly used as an in vitro inflammatory response model. TH...
of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate ...
of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined ...
Enterovirus 71 (EV71) is one of the causative agents of hand, foot, and mouth disease (HFMD), which sometimes leads to severe neurological disease and death in the Asia–Pacific region. In Chinese medicine, HFMD is caused mainly by an accumulation of dam