产品名称Anti-DFNA5/GSDME antibody 分子量55 kDa 种属反应性Human,Mouse,Rat 验证应用WB,IHC-P,FC 抗体类型兔多抗 免疫原Recombinant protein within N-terminal human DFNA5/GSDME. 偶联Non-conjugated 性能 形态Liquid 浓度1 mg/mL. 存放说明Store at +4℃ after thawing. Aliquot store at -20℃...
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)—mutated in familial ageing-related hearing loss2—can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to ...
However, GzmB was very inefficient at cutting GSDME in vivo, thus only indirectly cleaved GSDME by activating pro-caspase-3 in target cells (Zhang et al., 2020). Meanwhile, the majority of tumor cells silence caspase-3 and GSDME expression to evade immune surveillance. Therefore, GzmA-...