g9a介导的histone h3 lysine9甲基化作用在自噬调控中的分子基础论文 热度: citrullinated histone h3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients.[2 热度: A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti...
citrullinated histone H3elderlyNeutrophil extracellular traps play key roles in the necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the relationships between neutrophil extracellular traps formation and the distribution and phase of vasculitis are ...
g9a介导的histone h3 lysine9甲基化作用在自噬调控中的分子基础论文 热度: citrullinated histone h3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients.[2 热度: A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti...
CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock. Current biomarkers for sepsis are limited by their non-specificity, short half-life, and insensitive response to therapy. Recently, we have demonstrated that citrullinated histone H3(CitH3) is released into the blood...
[14,15,16], while the ROS species promote NETosis by inducing gradual separation and loss of the nuclear membrane with the release of chromatin outside the cell through membrane pores. Cellular lysis with a final release of DNA, citrullinated histones (citH3), and other intracellular granules ...
Neutrophil extracellular traps (NETs) are a meshwork of DNA and granule proteins, including citrullinated histone 3 (H3cit), neutrophil elastase (NE), and myeloperoxidase (MPO), released by neutrophils in response to stimulants such as phorbol 12-myristate 13-acetate (PMA)[8]. Recent researches...
Contra capture protein arrays were citrullinated by rmPAD2 (40U/mg) in the citrullination buffer at 55 °C for 3 h (11). After citrullination, arrays were either probed with antibodies against anti-citrullinated fibrinogen antibody or anti-cit-Histone H3 to confirm successful on-array ...
citrullinated histone H3elderlyNeutrophil extracellular traps play key roles in the necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the relationships between neutrophil extracellular traps formation and the distribution and phase of vasculitis are ...
Methods We included 37 RA, 25 healthy control, and 46 subjects "at-risk" for RA based on familial RA and/or serum anti-citrullinated protein antibody (ACPA) positivity. Paired serum, sputum, and saliva were evaluated for anti-PAD4 and anti-PAD3/4 using immunoprecipitation and ACPA using ...
Peptidylarginine deiminase (PAD) enzymes have emerged as key participants in the pathogenesis of rheumatoid arthritis (RA) due to their expression in inflamed RA synovium and generation of citrullinated autoantigens, hallmark targets of the immune response in RA. Autoantibodies to PAD4, a nuclear ...