citrullinated histone H3elderlyNeutrophil extracellular traps play key roles in the necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the relation
Notably, a fraction of neutrophils in SARS-CoV-2 autopsy lungs, particularly in the interstitium, were characterized by NET formation as indicated by positive staining for citrullinated histone H3 (Figure 4c, c (iii)). AAT and ST6GAL1 response to IL-6 and SARS- CoV-2 ARDS and nsARDS ...
4G). In addition, melatonin treatment induced a higher level of neutrophil extracellular traps (NETs) in the tumor microenvironment of PAAD as indicated by increased citrullinated histone H3 (H3Cit) and myeloperoxidase (MPO) staining49 (Fig. 4H). Production of ROS was reported as a key ...
BY-K1053R Anti-CCP (cyclic citrullinated peptide)??兔抗瓜氨酸环肽抗体 BY-K0620R Anti-Histone H3-like protein??抗组蛋白H3样抗体(C端抗体) BY-K0222R Anti-NR2B/NMDAR2B(N-Methyl-d-Asprtate receptor 2B)??谷氨酸受体2B抗体 BY-K0372R Anti-CD73(5′-nucleotidase cytosolicⅡ)??胞浆-5′-核苷酸...
TLR, toll-like receptor; NE, neutrophil elastase; ILs, interleukins; NOX, nicotinamide-adenine-dinuleotide-phosphate oxidase; ROS, reactive oxidative species; MPO, myeloperoxidase; CitH, citrullinated histones; PAD4, peptidyl arginine deiminase 4; GSDMD, pore-forming protein Gasdermin D; LPS, ...
Thus, proteins citrullinated by PAD trigger antibody responses as well as T-cell responses in ACPA-positive RA.PAD2 and PAD4 enzymes have previously been detected in synovial tissue from RA patients and their expression levels were found to be correlated with the intensity of inflammation (Foul...
Objective Mechanisms leading to anti–citrullinated protein antibody (ACPA) generation in rheumatoid arthritis (RA) are hypothesized to originate in the lung. We undertook this study to understand associations between neutrophil extracellular trap (NET) formation in the lung and local ACPA generation in...
Human fibrinogen, human alpha-enolase (ENO1), human histone H3, and human serum albumin (HSA) were citrullinated in vitro by PAD2 or PAD4. The total degree of citrullination was determined using the anti-modified citrulline approach. Antibody binding to native and citrullinated proteins was ...
Methods We included 37 RA, 25 healthy control, and 46 subjects "at-risk" for RA based on familial RA and/or serum anti-citrullinated protein antibody (ACPA) positivity. Paired serum, sputum, and saliva were evaluated for anti-PAD4 and anti-PAD3/4 using immunoprecipitation and ACPA using ...
FIG. 6: Vimentin 28-49 helper epitope inserted into the CDRH3 site of the huIgG1 antibody DNA double expression vector is processed, citrullinated and presented in vivo. HLA-DR4 transgenic mice were immunised with the antibody DNA construct via gene gun once a week for 3 consecutive weeks. ...