Drugs used in PD Dopaminomimetic Drugs Therapeutic Drugs Central anti-cholinergic Drugs 1. Dopaminomimetic Drugs Levodopa (L-dopa, 左旋多巴) Dopamine itself does not cross the blood-brain barrier. L-dopa is a metabolic precursor of dopamine. It could p rates into the brain, where it is de...
Estimation of anticholinergic effects of the atypical antidepressant, mianserin by antagonism against pilocarpine-induced salivation The effect of cholinergic drugs on the tremor induced by subcutaneous (s.c.) injection of a 1 v/v% phenol solution was investigated. Male dd-Y strain mice ... K ...
Anti‐Cholinergic Effects of Quinidine, Disopyramide, and Procainamide in Isolated Atrial MyocytesMediation by Different Molecular Mechan... Effects of quinidine, disopyramide, and procainamide on the acetylcholine (ACh)-induced K+channel current were examined in single atrial cells, using ... T Nakajim...
This balance can be restored by: (1) reducing cholinergic function with traditional antiparkinsonian drugs which block the muscarinic actions of acetylcholine (such as atropine, hyoscine, benzhexol, orphenadrine), or (2) by augmenting dopaminergic function. As dopamine does not readily cross the ...
(Duvoisin, 1967). It has been postulated that dopamine depletion results in a state of cholinergic hypersensitivity which can be reversed by anticholinergics, such as benztropine. In 1969, Coyle and Snyder suggested that the mechanism of the therapeutic action of the anticholinergic drugs in PD ...
药理学英文课件:Antiparkinsonism Drugs C20ξ1Antiparkinsonism Drugs Etiologicalfactor substantianigraandstriatum:Dopaminergicnerve Cholinergicnerve GroupsofDrugs DopaminedrugsCentralanticholinergicdrugs ClinicalsymptomofParkinson'sdisease1.skeletalrigidity2.movebradykinesia3.tremorrestingtremor (一)L-Dopa [Effectsand...
Effect of Bacopa monniera on animal models of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats D.V. Siva Sankar (Ed.), Molecular Aspects of Asian Medicines, PJD Publications, New York (1999) Google Scholar 26 G Shanker, HK Singh Anxiolytic profile of standardiz...
期刊名称:《Anti-Inflammatory & Anti-allergy Agents in Medicinal Chemistry》 | 2011年第5期 关键词: Alpha-1-antitrypsin; apoptosis; hepatocellular proliferation; autophagy.; 2.Novel Carriers for Controlled Site Specific Delivery of Anti-Inflammatory Agents 机译:用于控制特定部位的抗炎药的新型载体 作...
in nausea and vomiting require further research. For these reasons, the exact mechanisms by which scopolamine prevents nausea and vomiting are unclear. The proposed pathways generally involve scopolamine-inhibiting cholinergic communications between higher CNS centers, the reticular formation in the brainstem...
Antimuscarinic drugs, such asoxybutynin,tolterodine, trospium,darifenacin, andsolifenacin, are considered a first-linepharmacotherapyforOABsyndrome. Chemically, these drugs, being tertiary or quaternary amines, are structurally similar toacetylcholine.Tolterodineis atertiary aminewith lessside effectsand better...