Anti CD20 (Rituximab) therapy in refractory pediatric rheumatic diseasesJoel ReisFrancisca AguiarIva Brito
2, 3, 4, 5 These patients can have severe and progressive disease despite prolonged antimicrobial therapy, which can result in drug toxicity and therapeutic failure. Rituximab is a chimeric mAb directed against human CD20 on mature B cells and plasmablasts that causes rapid and sustained depletion...
Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb). In this study, we show that CD16 ligation on primary human NK cells by the anti-CD20...
Tony, "Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and b cell subset regeneration after repeated treatment," Arthritis and Rheumatism, vol. 58, no. 6, pp. 1566-1575, 2008.Roll P, Dorner T, Tony HP. Anti-CD20 therapy in patients with rheumatoid arthritis:...
Agents which have efficacy in the treatment of autoimmune disorders have been utilized as therapy for established chronic GVHD and are associated with ... V Ratanatharathorn,L Ayash,HM Lazarus,... - 《Bone Marrow Transplantation》 被引量: 1159发表: 2001年 Anti-CD20 Chimeric Monoclonal Antibody ...
IDEC-C2B8 is a chimeric monoclonal antibody (MoAb) directed against the B-cell–specific antigen CD20 expressed on non-Hodgkin's lymphomas (NHL). The MoAb mediates complement and antibody-dependent cell-mediated cytotoxicity and has direct antiproliferative effects against malignant B-cell lines in ...
The clinical activity of rituximab, a chimeric monoclonal antibody which binds to the CD20 antigen, was evaluated as a single first-line therapy for patients with follicular non-Hodgkin lymphoma (NHL). Fifty patients with follicular CD20+ NHL and a low tumor burden were analyzed for clinical and...
Anti-CD20 therapy of ocular disordersdoi:CN1845755 A本申请描述了利用结合CD-20的拮抗剂诸如抗体的眼部疾病的治疗。 The present application describes the use of binding CD-20 antagonist treatment of eye diseases such as antibodies.保罗·G·布鲁尼塔...
Rituximab (IDEC-C2B8, Mabthera, Rituxan), a chimeric monoclonal antibody against the B-cell specific CD20-antigen, has been demonstrated to be effective in... A Harjunp??,T Wiklund,J Collan,... - 《Leuk Lymphoma》 被引量: 174发表: 2001年 Imaging and therapy with rituximab anti-CD20 imm...
B cell-targeted therapy with anti-CD20 monoclonal antibody in a mouse model of Graves' hyperthyroidism. Clin Exp Immunol. 2011;163(3):309-317.Ueki I, Abiru N, Kobayashi M, Nakahara M, Ichikawa T, Eguchi K, et al. B cell-targeted therapy with anti-CD20 monoclonal antibody in a mouse ...