In Vivo: A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab...
E. coli - derived recombinant Human CD20 / MS4A1 (Ile143-Ser188). 别名icon B-lymphocyte surface antigen B1,Membrane-spanning 4-domains subfamily A member 1,MS4A1,Leukocyte surface antigen Leu-16,B-lymphocyte antigen CD20,Bp35,CD20,Drug Target Uniprot IDicon P11836 Noteicon For resea...
doi:10.1200/JCO.2024.42.16_suppl.302623026#Background:TRS005 is a novel anti-CD20 antibody-drug conjugate targeting CD20 positive tumor cells to deliver MMAE into the cells via receptor-mediated endocytosis. The aim of this study was to evaluate the safety, pharmacokinetics, and anti-tumor ...
Reassessment of Anti-CD20 Therapy in Lymphoid Malignancies: Impact, Limitations, and New Directions The addition of anti-CD20 monoclonal antibodies to Friedberg,Jonathan,W.,... - 《Oncology》 被引量: 4发表: 2017年 加载更多来源期刊 Analyst 研究点推荐 monoclonal antibody drug products CYSTEINE PROTE...
摘要: Use of a type II anti-cd20 Antibody is useful for preparing medicine to treat cancer that expresses CD20 in combination with a proteasome inhibitor.Pharmaceutical composition containing such a combination and Kit thereof.收藏 引用 批量引用 报错 分享 ...
Dashboard Your Reading List, filled with our Editors’ Picks, articles, insights and news as well as your Saved Items and Reading History Explore Our expert reviewed and hand selected specialty-specific information with exclusive critical insights and context Channels Cardiology Card...
MCLA-145 is a targeted drug capable of both T cell costimulation and checkpoint blockade which may have broad clinical utility. The preclinical data presented suggest MCLA-145 has the potential to be active as a monotherapy in settings where ICI treatments fail to improve patient outcomes. MCLA-...
Title: “Two Norwegian Researchers Discover Drug Against ME/CFS | Raising Awareness for ME/CFS” http://raisingawarenessfo... Publication: European Society for ME Research and Knowledge Title: “Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome:...
We aimed to elucidate the effects of iguratimod, a widely used anti-rheumatic drug with no severe side effects, on chronic experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Iguratimod was orally administered to mice immunised with myelin oligodendrocyte glyc...
HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is effective but requires lifelong drug administration owing to a stable reservoir of latent proviruses integrated into the genome of CD4+ T cells1. Immunotherapy